Inhibition of the UV induction of sister-chromatid exchanges in ICR-2A frog cells by pretreatment with γ-rays

Chuck C.K. Chao*, Barry S. Rosenstein

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations

Abstract

Exposure of ICR-2A cells to UV induced the formation of sister-chromatid exchanges (SCEs). However, pretreatment of UV-irradiated cells with γ-rays resulted in a reduction in the level of SCEs. This effect was observed over a range of UV fluences (1-5 J/m2) and γ-ray doses (50-500 rad). In addition, the deprassion of UV-induced SCEs was greatest when the UV treatment was performed within 3 h after γ-irradiation. At later times the level of SCEs approached that of cells exposed only to UV.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalMutation Research Letters
Volume139
Issue number1
DOIs
StatePublished - 01 1984
Externally publishedYes

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