TY - JOUR
T1 - Inhibitory effects of Bichalcone derivatives on Superoxide anion generation (O2 •-) and elastase release by activated human neutrophils in response to FMLP/CB
AU - Reddy, Mopur Vijaya Bhaskar
AU - Hwang, Tsong Long
AU - Wu, Tian Shung
PY - 2016
Y1 - 2016
N2 - Chalcones have a distinctive 1,3-diaryl propenone skeleton and exert numerous biological effects. Previously we synthesized (1a-23) bichalcones through the piperazine Mannich base linkage with different substitution on the both ring-B of the chalcone moieties. These compounds were subjected into the inhibitory effects on Formyl-Met-Leu-Phe (FMLP) and cytochalasin B (CB) stimulated O2 •- generation and elastase release in human neutrophils. Among the tested compounds, 3-23 were exhibited potent elastase release inhibitory effects in activated human neutrophils with the IC50 values ranges from 4.98 μM to 50.87 μM.
AB - Chalcones have a distinctive 1,3-diaryl propenone skeleton and exert numerous biological effects. Previously we synthesized (1a-23) bichalcones through the piperazine Mannich base linkage with different substitution on the both ring-B of the chalcone moieties. These compounds were subjected into the inhibitory effects on Formyl-Met-Leu-Phe (FMLP) and cytochalasin B (CB) stimulated O2 •- generation and elastase release in human neutrophils. Among the tested compounds, 3-23 were exhibited potent elastase release inhibitory effects in activated human neutrophils with the IC50 values ranges from 4.98 μM to 50.87 μM.
KW - Mannich base linked bichalcones
KW - Superoxide generation (O ) and elastase release
UR - http://www.scopus.com/inward/record.url?scp=85018208611&partnerID=8YFLogxK
M3 - 文章
AN - SCOPUS:85018208611
SN - 0975-5071
VL - 8
SP - 172
EP - 176
JO - Der Pharmacia Lettre
JF - Der Pharmacia Lettre
IS - 20
ER -