Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils

Yu Liang Yang; Fang Rong Chang; Tsong Long Hwang; Wen Te Chang; Yang Chang Wu

doi:10.1055/s-2004-815544

Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils

Yu Liang Yang
, Fang Rong Chang
, Tsong Long Hwang
, Wen Te Chang
, Yang Chang Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Eleven ent-kauranes, isolated from the fresh stems of Annona squamosa L. (Annonaceae), were subjected to assays on the generation of superoxide anion (O₂^.-) by human neutrophils. Except for ent-kaur-16-en-19-oic acid, 16β,17-dihydroxy-ent-kauran-19-al, and 16α,17-dihydroxy-ent-kauran-19-al, all ent-kauranes showed significant inhibitory effect on O₂^.- generation in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP/ CB). In contrast, phorbol myristate acetate (PMA)-induced O₂^.- generation was not suppressed by any ent-kauranes. Especially, ent-kaur-16-en-19-oic acid could significantly increase O₂^.- production. The structure-activity relationship of these compounds is also discussed herein. Furthermore, the effect of ent-kauranes on nitric oxide generation by NR8383 macrophages in response to lipopolysaccharide (LPS) was examined. None of the compounds showed an inhibitory effect on nitric oxide generation.

Original language	English
Pages (from-to)	256-258
Number of pages	3
Journal	Planta Medica
Volume	70
Issue number	3
DOIs	https://doi.org/10.1055/s-2004-815544
State	Published - 03 2004

Access to Document

10.1055/s-2004-815544

Cite this

@article{c32531e0d21e474a8f287edd63adafb3,

title = "Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils",

abstract = "Eleven ent-kauranes, isolated from the fresh stems of Annona squamosa L. (Annonaceae), were subjected to assays on the generation of superoxide anion (O2.-) by human neutrophils. Except for ent-kaur-16-en-19-oic acid, 16β,17-dihydroxy-ent-kauran-19-al, and 16α,17-dihydroxy-ent-kauran-19-al, all ent-kauranes showed significant inhibitory effect on O2.- generation in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP/ CB). In contrast, phorbol myristate acetate (PMA)-induced O2.- generation was not suppressed by any ent-kauranes. Especially, ent-kaur-16-en-19-oic acid could significantly increase O2.- production. The structure-activity relationship of these compounds is also discussed herein. Furthermore, the effect of ent-kauranes on nitric oxide generation by NR8383 macrophages in response to lipopolysaccharide (LPS) was examined. None of the compounds showed an inhibitory effect on nitric oxide generation.",

author = "Yang, \{Yu Liang\} and Chang, \{Fang Rong\} and Hwang, \{Tsong Long\} and Chang, \{Wen Te\} and Wu, \{Yang Chang\}",

year = "2004",

month = mar,

doi = "10.1055/s-2004-815544",

language = "英语",

volume = "70",

pages = "256--258",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "3",

}

TY - JOUR

T1 - Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils

AU - Yang, Yu Liang

AU - Chang, Fang Rong

AU - Hwang, Tsong Long

AU - Chang, Wen Te

AU - Wu, Yang Chang

PY - 2004/3

Y1 - 2004/3

N2 - Eleven ent-kauranes, isolated from the fresh stems of Annona squamosa L. (Annonaceae), were subjected to assays on the generation of superoxide anion (O2.-) by human neutrophils. Except for ent-kaur-16-en-19-oic acid, 16β,17-dihydroxy-ent-kauran-19-al, and 16α,17-dihydroxy-ent-kauran-19-al, all ent-kauranes showed significant inhibitory effect on O2.- generation in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP/ CB). In contrast, phorbol myristate acetate (PMA)-induced O2.- generation was not suppressed by any ent-kauranes. Especially, ent-kaur-16-en-19-oic acid could significantly increase O2.- production. The structure-activity relationship of these compounds is also discussed herein. Furthermore, the effect of ent-kauranes on nitric oxide generation by NR8383 macrophages in response to lipopolysaccharide (LPS) was examined. None of the compounds showed an inhibitory effect on nitric oxide generation.

AB - Eleven ent-kauranes, isolated from the fresh stems of Annona squamosa L. (Annonaceae), were subjected to assays on the generation of superoxide anion (O2.-) by human neutrophils. Except for ent-kaur-16-en-19-oic acid, 16β,17-dihydroxy-ent-kauran-19-al, and 16α,17-dihydroxy-ent-kauran-19-al, all ent-kauranes showed significant inhibitory effect on O2.- generation in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP/ CB). In contrast, phorbol myristate acetate (PMA)-induced O2.- generation was not suppressed by any ent-kauranes. Especially, ent-kaur-16-en-19-oic acid could significantly increase O2.- production. The structure-activity relationship of these compounds is also discussed herein. Furthermore, the effect of ent-kauranes on nitric oxide generation by NR8383 macrophages in response to lipopolysaccharide (LPS) was examined. None of the compounds showed an inhibitory effect on nitric oxide generation.

UR - https://www.scopus.com/pages/publications/1842431875

U2 - 10.1055/s-2004-815544

DO - 10.1055/s-2004-815544

M3 - 文章

C2 - 15114504

AN - SCOPUS:1842431875

SN - 0032-0943

VL - 70

SP - 256

EP - 258

JO - Planta Medica

JF - Planta Medica

IS - 3

ER -

Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils

Abstract

Access to Document

Other files and links

Fingerprint

Cite this