Inhibitory effects of propofol on Th17 cell differentiation

Chi Chien Lin; Der Yuan Chen; Kuo Tung Tang; Ya Hsuan Chao; Ching Hui Shen; Ping Wing Lui

doi:10.1080/08923973.2017.1327962

Inhibitory effects of propofol on Th17 cell differentiation

Chi Chien Lin, Der Yuan Chen, Kuo Tung Tang, Ya Hsuan Chao, Ching Hui Shen, Ping Wing Lui^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

Propofol (2,6-diisopropylphenol) is probably the most widely used intravenous anesthetic agent in daily practice. It has been reported to show immunomodulatory activity. However, the effect of propofol on the differention of T cells remains unclear. In this study, we demonstrated for the first time that propofol inhibited both interleukin (IL)-6 plus transforming growth factor-β (TGF-β)-induced Th17 cell differentiation in vitro and in LPS-challenged mice. Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation. These data extend our knowledge of the immunosuppressive effects of propofol and their underlying mechanism.

Original language	English
Pages (from-to)	211-218
Number of pages	8
Journal	Immunopharmacology and Immunotoxicology
Volume	39
Issue number	4
DOIs	https://doi.org/10.1080/08923973.2017.1327962
State	Published - 04 07 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Propofol
Th17
anesthetic
differentiation
signal transducer and activator of transcription (STAT 3)
suppressor of cytokine signaling-3

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10.1080/08923973.2017.1327962

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title = "Inhibitory effects of propofol on Th17 cell differentiation",

abstract = "Propofol (2,6-diisopropylphenol) is probably the most widely used intravenous anesthetic agent in daily practice. It has been reported to show immunomodulatory activity. However, the effect of propofol on the differention of T cells remains unclear. In this study, we demonstrated for the first time that propofol inhibited both interleukin (IL)-6 plus transforming growth factor-β (TGF-β)-induced Th17 cell differentiation in vitro and in LPS-challenged mice. Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation. These data extend our knowledge of the immunosuppressive effects of propofol and their underlying mechanism.",

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T1 - Inhibitory effects of propofol on Th17 cell differentiation

AU - Lin, Chi Chien

AU - Chen, Der Yuan

AU - Tang, Kuo Tung

AU - Chao, Ya Hsuan

AU - Shen, Ching Hui

AU - Lui, Ping Wing

PY - 2017/7/4

Y1 - 2017/7/4

N2 - Propofol (2,6-diisopropylphenol) is probably the most widely used intravenous anesthetic agent in daily practice. It has been reported to show immunomodulatory activity. However, the effect of propofol on the differention of T cells remains unclear. In this study, we demonstrated for the first time that propofol inhibited both interleukin (IL)-6 plus transforming growth factor-β (TGF-β)-induced Th17 cell differentiation in vitro and in LPS-challenged mice. Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation. These data extend our knowledge of the immunosuppressive effects of propofol and their underlying mechanism.

AB - Propofol (2,6-diisopropylphenol) is probably the most widely used intravenous anesthetic agent in daily practice. It has been reported to show immunomodulatory activity. However, the effect of propofol on the differention of T cells remains unclear. In this study, we demonstrated for the first time that propofol inhibited both interleukin (IL)-6 plus transforming growth factor-β (TGF-β)-induced Th17 cell differentiation in vitro and in LPS-challenged mice. Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation. These data extend our knowledge of the immunosuppressive effects of propofol and their underlying mechanism.

KW - Propofol

KW - Th17

KW - anesthetic

KW - differentiation

KW - signal transducer and activator of transcription (STAT 3)

KW - suppressor of cytokine signaling-3

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DO - 10.1080/08923973.2017.1327962

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SN - 0892-3973

VL - 39

SP - 211

EP - 218

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 4

ER -

Inhibitory effects of propofol on Th17 cell differentiation

Abstract

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