Inhibitory effects of propofol on Th17 cell differentiation

Chi Chien Lin, Der Yuan Chen, Kuo Tung Tang, Ya Hsuan Chao, Ching Hui Shen, Ping Wing Lui*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations


Propofol (2,6-diisopropylphenol) is probably the most widely used intravenous anesthetic agent in daily practice. It has been reported to show immunomodulatory activity. However, the effect of propofol on the differention of T cells remains unclear. In this study, we demonstrated for the first time that propofol inhibited both interleukin (IL)-6 plus transforming growth factor-β (TGF-β)-induced Th17 cell differentiation in vitro and in LPS-challenged mice. Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation. These data extend our knowledge of the immunosuppressive effects of propofol and their underlying mechanism.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalImmunopharmacology and Immunotoxicology
Issue number4
StatePublished - 04 07 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.


  • Propofol
  • Th17
  • anesthetic
  • differentiation
  • signal transducer and activator of transcription (STAT 3)
  • suppressor of cytokine signaling-3


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