Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle

Ching Yi Yiu; Shih Ying Chen; Li Kwan Chang; Ya Fang Chiu; Tsuey Pin Lin

doi:10.3390/molecules15107115

Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle

Ching Yi Yiu, Shih Ying Chen, Li Kwan Chang, Ya Fang Chiu, Tsuey Pin Lin^*

^*Corresponding author for this work

Department of Microbiology and Immunology

Research output: Contribution to journal › Journal Article › peer-review

59 Scopus citations

Abstract

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.

Original language	English
Pages (from-to)	7115-7124
Number of pages	10
Journal	Molecules
Volume	15
Issue number	10
DOIs	https://doi.org/10.3390/molecules15107115
State	Published - 10 2010

Keywords

Antiviral activity
EBV
Resveratrol

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10.3390/molecules15107115

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title = "Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle",

abstract = "Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.",

keywords = "Antiviral activity, EBV, Resveratrol",

author = "Yiu, {Ching Yi} and Chen, {Shih Ying} and Chang, {Li Kwan} and Chiu, {Ya Fang} and Lin, {Tsuey Pin}",

year = "2010",

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AU - Yiu, Ching Yi

AU - Chen, Shih Ying

AU - Chang, Li Kwan

AU - Chiu, Ya Fang

AU - Lin, Tsuey Pin

PY - 2010/10

Y1 - 2010/10

N2 - Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.

AB - Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.

KW - Antiviral activity

KW - EBV

KW - Resveratrol

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U2 - 10.3390/molecules15107115

DO - 10.3390/molecules15107115

M3 - 文章

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JO - Molecules

JF - Molecules

IS - 10

ER -

Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle

Abstract

Keywords

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