Injectable drug-loaded nanocarriers for lung cancer treatments

Huang Ping Yu, Ibrahim A. Aljuffali, Jia You Fang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Different types of injectable nanoparticles, including metallic nanoparticles, polymeric nanocarriers, dendrimers, liposomes, niosomes, and lipid nanoparticles, have been employed to load drugs for lung delivery. Nanoparticles used for lung delivery offer some benefits over conventional formulations, including increased solubility, enhanced stability, improved epithelium permeability and bioavailability, prolonged half-life, tumor targeting, and minimal side effects. In recent years, the concept of using injectable nanocarriers as vehicles for drug delivery has attracted increasing attention. This review highlights recent developments using nanomedical approaches for drug targeting to the lungs. We systematically introduce the concepts and amelioration mechanisms of the nanomedical techniques for lung cancer therapy. Passive targeting by modulating the nanoparticulate structure and the physicochemical properties is an option for efficient drug delivery to the lungs. In addition, active targeting such as antibody or peptide conjugation to nanoparticles is another efficient way to deliver the drugs to the targeted site. This review describes various nanocarriers loaded with anticancer drugs for passive or active targeting of lung malignancy. In this review, we principally focus on the nanomedical application in animal studies. The article excludes investigations limited to cell-based experiments. The review ends by anticipating future developments and trends.

Original languageEnglish
Pages (from-to)481-494
Number of pages14
JournalCurrent Pharmaceutical Design
Volume23
Issue number3
DOIs
StatePublished - 01 01 2017

Bibliographical note

Publisher Copyright:
© 2017 Bentham Science Publishers.

Keywords

  • Injection
  • Lung targeting
  • Lung tumor
  • Nanocarrier
  • Nanomedicine

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