Innate immunity to intracellular pathogens: Macrophage receptors and responses to microbial entry

Annette Plüddemann; Subhankar Mukhopadhyay; Siamon Gordon

doi:10.1111/j.1600-065X.2010.00989.x

Innate immunity to intracellular pathogens: Macrophage receptors and responses to microbial entry

Annette Plüddemann
, Subhankar Mukhopadhyay
, Siamon Gordon^*

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Review article › peer-review

144 Scopus citations

Abstract

Innate immunity to intracellular pathogens encompasses a range of interactions of cellular and humoral activities of the host with the invading microorganism, determining the outcome of infection. Here, we review the particular role of macrophage recognition receptors and effector responses in the uptake of microbes and their products. We place this in context and raise issues for discussion and further experimentation.

Original language	English
Pages (from-to)	11-24
Number of pages	14
Journal	Immunological Reviews
Volume	240
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-065X.2010.00989.x
State	Published - 03 2011
Externally published	Yes

Keywords

Innate immunity
Intracellular pathogens
Macrophages
Phagocytosis
Receptors

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10.1111/j.1600-065X.2010.00989.x

Cite this

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abstract = "Innate immunity to intracellular pathogens encompasses a range of interactions of cellular and humoral activities of the host with the invading microorganism, determining the outcome of infection. Here, we review the particular role of macrophage recognition receptors and effector responses in the uptake of microbes and their products. We place this in context and raise issues for discussion and further experimentation.",

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AB - Innate immunity to intracellular pathogens encompasses a range of interactions of cellular and humoral activities of the host with the invading microorganism, determining the outcome of infection. Here, we review the particular role of macrophage recognition receptors and effector responses in the uptake of microbes and their products. We place this in context and raise issues for discussion and further experimentation.

KW - Innate immunity

KW - Intracellular pathogens

KW - Macrophages

KW - Phagocytosis

KW - Receptors

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Innate immunity to intracellular pathogens: Macrophage receptors and responses to microbial entry

Abstract

Keywords

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