Innovative strategy with potential to increase hemodialysis efficiency and safety

Hsiao Chien Chen; Hsiu Chen Lin; Hsi Hsien Chen; Fu Der Mai; Yu Chuan Liu; Chun Mao Lin; Chun Chao Chang; Hui Yen Tsai; Chih Ping Yang

doi:10.1038/srep04425

Innovative strategy with potential to increase hemodialysis efficiency and safety

Hsiao Chien Chen
, Hsiu Chen Lin
, Hsi Hsien Chen
, Fu Der Mai
, Yu Chuan Liu^*
, Chun Mao Lin
, Chun Chao Chang
, Hui Yen Tsai
, Chih Ping Yang

^*Corresponding author for this work

Taipei Medical University

Research output: Contribution to journal › Journal Article › peer-review

38 Scopus citations

Abstract

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K₃ Fe(CN)₆ in saline solution can be significantly increased from 2.76, to 4.62 × 10^-6 cm s^-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

Original language	English
Article number	4425
Journal	Scientific Reports
Volume	4
DOIs	https://doi.org/10.1038/srep04425
State	Published - 21 03 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/srep04425

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title = "Innovative strategy with potential to increase hemodialysis efficiency and safety",

abstract = "Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 {\texttimes} 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70\% BUN and Crea are reduced by 47 and 59\%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.",

author = "Chen, \{Hsiao Chien\} and Lin, \{Hsiu Chen\} and Chen, \{Hsi Hsien\} and Mai, \{Fu Der\} and Liu, \{Yu Chuan\} and Lin, \{Chun Mao\} and Chang, \{Chun Chao\} and Tsai, \{Hui Yen\} and Yang, \{Chih Ping\}",

year = "2014",

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day = "21",

doi = "10.1038/srep04425",

language = "英语",

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journal = "Scientific Reports",

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AU - Chen, Hsiao Chien

AU - Lin, Hsiu Chen

AU - Chen, Hsi Hsien

AU - Mai, Fu Der

AU - Liu, Yu Chuan

AU - Lin, Chun Mao

AU - Chang, Chun Chao

AU - Tsai, Hui Yen

AU - Yang, Chih Ping

PY - 2014/3/21

Y1 - 2014/3/21

N2 - Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

AB - Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

UR - https://www.scopus.com/pages/publications/84898863749

U2 - 10.1038/srep04425

DO - 10.1038/srep04425

M3 - 文章

C2 - 24651843

AN - SCOPUS:84898863749

SN - 2045-2322

VL - 4

JO - Scientific Reports

JF - Scientific Reports

M1 - 4425

ER -

Innovative strategy with potential to increase hemodialysis efficiency and safety

Abstract

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