TY - JOUR
T1 - Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection
AU - Hung, Chao Hung
AU - Wang, Jing Houng
AU - Hu, Tsung Hui
AU - Chen, Chien Hung
AU - Chang, Kuo Chin
AU - Yen, Yi Hao
AU - Kuo, Yuan Hung
AU - Tsai, Ming Chao
AU - Lu, Sheng Nan
AU - Lee, Chuan Mo
PY - 2010/5/14
Y1 - 2010/5/14
N2 - AIM: To elucidate the role of insulin resistance (IR) and serum adiponectin level in hepatocellular carcinoma (HCC) associated with chronic hepatitis C. METHODS: Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed HCC. Homeostasis model assessment of IR (HOMA-IR) and serum adiponectin level were investigated in 188 patients with different stages of hepatitis C virus (HCV) infection. RESULTS: Among HCC patients, type 2 diabetics (DM) was more prevalent in HCV subjects (35.6%, n = 59) compared to hepatitis B virus (HBV; 12.7%, n = 63) or non-HBV, non-HCV cases (7.1%, n = 28). In patients with chronic hepatitis C, HCC subjects had higher blood sugar (P < 0.001), insulin level (P = 0.003) and HOMAIR (P = 0.018) than those with chronic hepatitis and advanced fibrosis. Age, male sex and body mass index were significantly associated with serum adiponectin level, whereas HOMA-IR was not. Based on stepwise logistic regression analysis, age (OR: 1.124, P < 0.001), serum insulin level (OR: 1.585, P < 0.001), HOMA-IR (OR: 0.495, P = 0.001), DM (OR: 11.601, P = 0.002) and male sex (OR: 3.877, P = 0.016) were independently associated with HCC. This result was similar even if the diabetic subjects were excluded for analysis. CONCLUSION: Insulin resistance measured by HOMAIR, regardless of the presence of diabetes, is significantly associated with HCC development in patients with chronic HCV infection.
AB - AIM: To elucidate the role of insulin resistance (IR) and serum adiponectin level in hepatocellular carcinoma (HCC) associated with chronic hepatitis C. METHODS: Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed HCC. Homeostasis model assessment of IR (HOMA-IR) and serum adiponectin level were investigated in 188 patients with different stages of hepatitis C virus (HCV) infection. RESULTS: Among HCC patients, type 2 diabetics (DM) was more prevalent in HCV subjects (35.6%, n = 59) compared to hepatitis B virus (HBV; 12.7%, n = 63) or non-HBV, non-HCV cases (7.1%, n = 28). In patients with chronic hepatitis C, HCC subjects had higher blood sugar (P < 0.001), insulin level (P = 0.003) and HOMAIR (P = 0.018) than those with chronic hepatitis and advanced fibrosis. Age, male sex and body mass index were significantly associated with serum adiponectin level, whereas HOMA-IR was not. Based on stepwise logistic regression analysis, age (OR: 1.124, P < 0.001), serum insulin level (OR: 1.585, P < 0.001), HOMA-IR (OR: 0.495, P = 0.001), DM (OR: 11.601, P = 0.002) and male sex (OR: 3.877, P = 0.016) were independently associated with HCC. This result was similar even if the diabetic subjects were excluded for analysis. CONCLUSION: Insulin resistance measured by HOMAIR, regardless of the presence of diabetes, is significantly associated with HCC development in patients with chronic HCV infection.
KW - Adiponectin
KW - Diabetes
KW - Hepatitis C virus
KW - Hepatocellular carcinoma
KW - Insulin resistance
UR - http://www.scopus.com/inward/record.url?scp=77952630118&partnerID=8YFLogxK
U2 - 10.3748/wjg.v16.i18.2265
DO - 10.3748/wjg.v16.i18.2265
M3 - 文章
C2 - 20458764
AN - SCOPUS:77952630118
SN - 1007-9327
VL - 16
SP - 2265
EP - 2271
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 18
ER -
