Integrated model for end-stage liver disease maybe superior to some other model for end-stage liver disease-based systems in addition to Child-Turcotte-Pugh and albumin-bilirubin scores in patients with hepatitis B virus-related liver cirrhosis and spontaneous bacterial peritonitis

Pin Cheng Chen, Bo Huan Chen, Chien Hao Huang*, Wen Juei Jeng, Yi Chung Hsieh, Wei Teng, Yi Cheng Chen, Yu Pin Ho, I. Shyan Sheen, Chun Yen Lin

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations

Abstract

Objectives For mortality prediction of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis, no direct comparisons have been made among the eight models, Child-Turcotte-Pugh (CTP) score, model for end-stage liver disease (MELD), MELD-Na, integrated MELD (iMELD) score, MELD to sodium (MESO) index, modification of the MELD scoring system (Refit MELD), Refit MELD-Na and Albumin-Bilirubin (ALBI) score. Materials and methods Between January 2005 and July 2017, 314 patients who met the criteria for liver cirrhosis with the first episode of SBP were enrolled in this retrospective study. Clinical and laboratory data were obtained at diagnosis. Patients were followed up until February 2018 or death. Results Patients were predominantly middle-aged male. Hepatitis B virus (HBV) infection accounted for the majority of the etiologies (41.7%) with 33.6% of the patients received antivirals. The in-hospital mortality rate was 39.8%. The cumulative 3-month and 6-month mortality rates were 51.6 and 60.2%, respectively. For patients with HBV related, not hepatitis C virus or alcohol related, liver cirrhosis, iMELD had the highest area under receiver operating characteristic curve (AUC) and was significantly superior to MELD, MESO, and Refit MELD in addition to CTP and ALBI scores in predicting 3-month and 6-month mortality. Conclusion For patients with HBV-related liver cirrhosis and SBP, iMELD had the highest AUC among these eight models and was significantly superior to MELD, MESO, and Refit MELD in addition to CTP and ALBI scores in predicting 3-month and 6-month mortalities.

Original languageEnglish
Pages (from-to)1256-1263
Number of pages8
JournalEuropean Journal of Gastroenterology and Hepatology
Volume31
Issue number10
DOIs
StatePublished - 01 10 2019

Bibliographical note

Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • 3-month and 6-month mortalities
  • Albumin-bilirubin score
  • Child-Turcotte-Pugh score
  • Hepatitis B virus-related liver cirrhosis
  • In-hospital
  • Model for end-stage liver disease-based scores
  • Spontaneous bacterial peritonitis

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