Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

Clinical Proteomic Tumor Analysis Consortium

doi:10.1016/j.celrep.2020.108276

Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

Clinical Proteomic Tumor Analysis Consortium

School of Medicine

Johns Hopkins University
National Institutes of Health
Pacific Northwest National Laboratory

Research output: Contribution to journal › Journal Article › peer-review

121 Scopus citations

Abstract

Hu et al. provide an integrated proteomic and glycoproteomic characterization of high-grade serous ovarian carcinomas and relevant non-tumor tissues, which reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes correlated with glycosylation alterations.

Original language	English
Article number	108276
Journal	Cell Reports
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.108276
State	Published - 20 10 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CPTAC
glycoproteomics
glycosylation
HGSC
high-grade serous ovarian carcinoma
mass spectrometry
proteomics
tumor clusters

Access to Document

10.1016/j.celrep.2020.108276

Cite this

@article{eda1d5ac6a074d62a4d563e6c917ac50,

title = "Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma",

abstract = "Hu et al. provide an integrated proteomic and glycoproteomic characterization of high-grade serous ovarian carcinomas and relevant non-tumor tissues, which reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes correlated with glycosylation alterations.",

keywords = "CPTAC, glycoproteomics, glycosylation, HGSC, high-grade serous ovarian carcinoma, mass spectrometry, proteomics, tumor clusters",

author = "\{Clinical Proteomic Tumor Analysis Consortium\} and Yingwei Hu and Jianbo Pan and Punit Shah and Minghui Ao and Thomas, \{Stefani N.\} and Yang Liu and Lijun Chen and Michael Schnaubelt and Clark, \{David J.\} and Henry Rodriguez and Boja, \{Emily S.\} and Tara Hiltke and Kinsinger, \{Christopher R.\} and Rodland, \{Karin D.\} and Li, \{Qing Kay\} and Jiang Qian and Zhen Zhang and Chan, \{Daniel W.\} and Hui Zhang and Akhilesh Pandey and Amanda Paulovich and Andrew Hoofnagle and Bing Zhang and Mani, \{D. R.\} and Liebler, \{Daniel C.\} and Ransohoff, \{David F.\} and David Fenyo and Tabb, \{David L.\} and Levine, \{Douglas A.\} and Eric Kuhn and White, \{Forest M.\} and Whiteley, \{Gordon A.\} and Heng Zhu and Shih, \{Ie Ming\} and Jasmin Bavarva and McDermott, \{Jason E.\} and Jeffrey Whiteaker and Ketchum, \{Karen A.\} and Clauser, \{Karl R.\} and Kelly Ruggles and Kimberly Elburn and Li Ding and Linda Hannick and Zimmerman, \{Lisa J.\} and Mark Watson and Mathangi Thiagarajan and Ellis, \{Matthew J.C.\} and Mauricio Oberti and Mehdi Mesri and Sanders, \{Melinda E.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = oct,

day = "20",

doi = "10.1016/j.celrep.2020.108276",

language = "英语",

volume = "33",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier B.V.",

number = "3",

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TY - JOUR

T1 - Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

AU - Clinical Proteomic Tumor Analysis Consortium

AU - Hu, Yingwei

AU - Pan, Jianbo

AU - Shah, Punit

AU - Ao, Minghui

AU - Thomas, Stefani N.

AU - Liu, Yang

AU - Chen, Lijun

AU - Schnaubelt, Michael

AU - Clark, David J.

AU - Rodriguez, Henry

AU - Boja, Emily S.

AU - Hiltke, Tara

AU - Kinsinger, Christopher R.

AU - Rodland, Karin D.

AU - Li, Qing Kay

AU - Qian, Jiang

AU - Zhang, Zhen

AU - Chan, Daniel W.

AU - Zhang, Hui

AU - Pandey, Akhilesh

AU - Paulovich, Amanda

AU - Hoofnagle, Andrew

AU - Zhang, Bing

AU - Mani, D. R.

AU - Liebler, Daniel C.

AU - Ransohoff, David F.

AU - Fenyo, David

AU - Tabb, David L.

AU - Levine, Douglas A.

AU - Kuhn, Eric

AU - White, Forest M.

AU - Whiteley, Gordon A.

AU - Zhu, Heng

AU - Shih, Ie Ming

AU - Bavarva, Jasmin

AU - McDermott, Jason E.

AU - Whiteaker, Jeffrey

AU - Ketchum, Karen A.

AU - Clauser, Karl R.

AU - Ruggles, Kelly

AU - Elburn, Kimberly

AU - Ding, Li

AU - Hannick, Linda

AU - Zimmerman, Lisa J.

AU - Watson, Mark

AU - Thiagarajan, Mathangi

AU - Ellis, Matthew J.C.

AU - Oberti, Mauricio

AU - Mesri, Mehdi

AU - Sanders, Melinda E.

PY - 2020/10/20

Y1 - 2020/10/20

N2 - Hu et al. provide an integrated proteomic and glycoproteomic characterization of high-grade serous ovarian carcinomas and relevant non-tumor tissues, which reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes correlated with glycosylation alterations.

AB - Hu et al. provide an integrated proteomic and glycoproteomic characterization of high-grade serous ovarian carcinomas and relevant non-tumor tissues, which reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes correlated with glycosylation alterations.

KW - CPTAC

KW - glycoproteomics

KW - glycosylation

KW - HGSC

KW - high-grade serous ovarian carcinoma

KW - mass spectrometry

KW - proteomics

KW - tumor clusters

UR - https://www.scopus.com/pages/publications/85092891972

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DO - 10.1016/j.celrep.2020.108276

M3 - 文章

C2 - 33086064

AN - SCOPUS:85092891972

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 3

M1 - 108276

ER -

Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

Abstract

Bibliographical note

UN SDGs

Keywords

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