Integration of brain tissue saturation monitoring in cardiopulmonary exercise testing in patients with heart failure

Shu Chun Huang, Carl P.C. Chen, Tieh-Cheng Fu, Yu Jen Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations

Abstract

Cerebral hypo-oxygenation during rest or exercise negatively impacts the exercise capacity of patients with heart failure with reduced ejection fraction (HF). However, in clinical cardiopulmonary exercise testing (CPET), cerebral hemodynamics is not assessed. NIRS is used to measure cerebral tissue oxygen saturation (SctO2) in the frontal lobe. This method is reliable and valid and has been utilized in several studies. SctO2 is lower during both rest and peak exercise in patients with HF than in healthy controls (66.3 ± 13.3% and 63.4 ± 13.8% vs. 73.1 ± 2.8% and 72 ± 3.2%). SctO2 at rest is significantly linearly correlated with peak VO2 (r = 0.602), oxygen uptake efficiency slope (r = 0.501), and brain natriuretic peptide (r =-0.492), all of which are recognized prognostic and disease severity markers, indicating its potential prognostic value. SctO2 is determined mainly by end-tidal CO2 pressure, mean arterial pressure, and hemoglobin in the HF population. This article demonstrates a protocol that integrates SctO2 using NIRS into incremental CPET on a calibrated bicycle ergometer.

Original languageEnglish
Article numbere60289
JournalJournal of Visualized Experiments
Volume2019
Issue number152
DOIs
StatePublished - 10 2019

Bibliographical note

Publisher Copyright:
© 2019 Journal of Visualized Experiments.

Keywords

  • Anemia
  • Cerebral Oxygenation
  • Cerebral Perfusion
  • Exercise
  • Hyperventilation
  • Issue 152
  • Medicine
  • Near-Infrared Spectroscopy

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