TY - JOUR
T1 - Interactions between guanabenz and clonidine in their antinociceptive effects in the rat
AU - Chan, Julie Y.H.
AU - Chan, Samuel H.H.
PY - 1987/4
Y1 - 1987/4
N2 - Based on the hot-plate algesiometric assay in conscious Sprague-Dawley rats, we observed that both guanabenz and clonidine, at a subcutaneous dose of 5 and 1 mg/kg, respectively, exhibited significant antinociceptive potencies. Paradoxical actions on the hot-plate responses, however, were exerted by guanabenz at lower doses, varying from hyperalgesia (1 mg/kg) to no effect (2 mg/kg). A pretreatment of clonidine (1 mg/kg) substantially potentiated the antinociceptive efficacy of the two latter doses, but failed to further augment the pain-suppressive action of guanabenz at 5 mg/kg. These interactive effects of the two α-adrenoceptor agonists suggest that they may share a common mechanism(s) in their analgesic actions.
AB - Based on the hot-plate algesiometric assay in conscious Sprague-Dawley rats, we observed that both guanabenz and clonidine, at a subcutaneous dose of 5 and 1 mg/kg, respectively, exhibited significant antinociceptive potencies. Paradoxical actions on the hot-plate responses, however, were exerted by guanabenz at lower doses, varying from hyperalgesia (1 mg/kg) to no effect (2 mg/kg). A pretreatment of clonidine (1 mg/kg) substantially potentiated the antinociceptive efficacy of the two latter doses, but failed to further augment the pain-suppressive action of guanabenz at 5 mg/kg. These interactive effects of the two α-adrenoceptor agonists suggest that they may share a common mechanism(s) in their analgesic actions.
UR - https://www.scopus.com/pages/publications/0023201715
U2 - 10.1016/0014-4886(87)90186-5
DO - 10.1016/0014-4886(87)90186-5
M3 - 文章
C2 - 3556516
AN - SCOPUS:0023201715
SN - 0014-4886
VL - 96
SP - 233
EP - 236
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -