Interleukin-15 Is Associated with Severity and Mortality in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Shih Chi Su, Maja Mockenhaupt, Pierre Wolkenstein, Ariane Dunant, Sabine Le Gouvello, Chun Bing Chen, Olivier Chosidow, Laurence Valeyrie-Allanore, Teresa Bellon, Peggy Sekula, Chuang Wei Wang, Martin Schumacher, Sylvia H. Kardaun, Shuen Iu Hung, Jean Claude Roujeau, Wen Hung Chung*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

102 Scopus citations

Abstract

Early diagnosis and prognosis monitoring for Stevens-Johnson syndrome/toxic epidermal necrolysis (TEN) still remain a challenge. This study aims to explore any cytokine/chemokine with prognostic potential in Stevens-Johnson syndrome/TEN. Through screening a panel of 28 serological factors, IL-6, IL-8, IL-15, tumor necrosis factor-α, and granulysin were upregulated in patients with Stevens-Johnson syndrome/TEN and selected for the further validation in total 155 patients with Stevens-Johnson syndrome/TEN, including 77 from Taiwan and 78 from the Registry of Severe Cutaneous Adverse Reactions. Among these factors evaluated, the levels of IL-15 (r = 0.401; P < 0.001) and granulysin (r = 0.223; P = 0.026) were significantly correlated with the disease severity in 112 samples after excluding patients with insufficient data to calculate the score of TEN. In addition, IL-15 was also associated with mortality (P = 0.002; odds ratio, 1.09; 95% confidence interval, 1.03–1.14; P = 0.001; adjusted odds ratio, 1.10; 95% confidence interval, 1.04–1.16). Consistent results were obtained after the exclusion of Taiwanese patients with sepsis to rule out possible confounders. Moreover, IL-15 was shown to enhance cytotoxicity of cultured natural killer cells and blister cells from patients with TEN. Our findings highlight a usefulness of IL-15 in prognosis monitoring and therapeutic intervention of this devastating condition.

Original languageEnglish
Pages (from-to)1065-1073
Number of pages9
JournalJournal of Investigative Dermatology
Volume137
Issue number5
DOIs
StatePublished - 05 2017

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