International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors

Jörg Hamann; Gabriela Aust; Demet Araç; Felix B. Engel; Caroline Formstone; Robert Fredriksson; Randy A. Hall; Breanne L. Harty; Christiane Kirchhoff; Barbara Knapp; Arunkumar Krishnan; Ines Liebscher; Hsi Hsien Lin; David C. Martinelli; Kelly R. Monk; Miriam C. Peeters; Xianhua Piao; Simone Prömel; Torsten Schöneberg; Thue W. Schwartz; Kathleen Singer; Martin Stacey; Yuri A. Ushkaryov; Mario Vallon; Uwe Wolfrum; Mathew W. Wright; Lei Xu; Tobias Langenhan; Helgi B. Schiöth

doi:10.1124/pr.114.009647

International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors

Jörg Hamann^*
, Gabriela Aust
, Demet Araç
, Felix B. Engel
, Caroline Formstone
, Robert Fredriksson
, Randy A. Hall
, Breanne L. Harty
, Christiane Kirchhoff
, Barbara Knapp
, Arunkumar Krishnan
, Ines Liebscher
, Hsi Hsien Lin
, David C. Martinelli
, Kelly R. Monk
, Miriam C. Peeters
, Xianhua Piao
, Simone Prömel
, Torsten Schöneberg
, Thue W. Schwartz

Kathleen Singer, Martin Stacey, Yuri A. Ushkaryov, Mario Vallon, Uwe Wolfrum, Mathew W. Wright, Lei Xu, Tobias Langenhan, Helgi B. Schiöth

^*Corresponding author for this work

Department of Microbiology and Immunology

University of Amsterdam
Research
The University of Chicago
Friedrich-Alexander University Erlangen-Nürnberg
King's College London
Uppsala University
Emory University
Washington University St. Louis
University of Hamburg
Johannes Gutenberg University Mainz
Leipzig University
Stanford University
Leiden University
University of Copenhagen
Boston Children's Hospital
University of Leeds
Medway School of Pharmacy
European Molecular Biology Laboratory
University of Rochester
University of Würzburg

Research output: Contribution to journal › Journal Article › peer-review

434 Scopus citations

Abstract

The Adhesion family forms a large branch of the pharmacologically important super-family of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Original language	English
Pages (from-to)	338-367
Number of pages	30
Journal	Pharmacological Reviews
Volume	67
Issue number	2
DOIs	https://doi.org/10.1124/pr.114.009647
State	Published - 23 02 2015

Bibliographical note

Publisher Copyright:
© 2015 by The American Society for Pharmacology and Experimental Therapeutics.

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10.1124/pr.114.009647

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Hamann, J., Aust, G., Araç, D., Engel, F. B., Formstone, C., Fredriksson, R., Hall, R. A., Harty, B. L., Kirchhoff, C., Knapp, B., Krishnan, A., Liebscher, I., Lin, H. H., Martinelli, D. C., Monk, K. R., Peeters, M. C., Piao, X., Prömel, S., Schöneberg, T., ... Schiöth, H. B. (2015). International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors. Pharmacological Reviews, 67(2), 338-367. https://doi.org/10.1124/pr.114.009647

@article{df25af264a554c3ab042f4ab9fc88c90,

title = "International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors",

abstract = "The Adhesion family forms a large branch of the pharmacologically important super-family of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.",

author = "J{\"o}rg Hamann and Gabriela Aust and Demet Ara{\c c} and Engel, \{Felix B.\} and Caroline Formstone and Robert Fredriksson and Hall, \{Randy A.\} and Harty, \{Breanne L.\} and Christiane Kirchhoff and Barbara Knapp and Arunkumar Krishnan and Ines Liebscher and Lin, \{Hsi Hsien\} and Martinelli, \{David C.\} and Monk, \{Kelly R.\} and Peeters, \{Miriam C.\} and Xianhua Piao and Simone Pr{\"o}mel and Torsten Sch{\"o}neberg and Schwartz, \{Thue W.\} and Kathleen Singer and Martin Stacey and Ushkaryov, \{Yuri A.\} and Mario Vallon and Uwe Wolfrum and Wright, \{Mathew W.\} and Lei Xu and Tobias Langenhan and Schi{\"o}th, \{Helgi B.\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Pharmacology and Experimental Therapeutics.",

year = "2015",

month = feb,

day = "23",

doi = "10.1124/pr.114.009647",

language = "英语",

volume = "67",

pages = "338--367",

journal = "Pharmacological Reviews",

issn = "0031-6997",

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Hamann, J, Aust, G, Araç, D, Engel, FB, Formstone, C, Fredriksson, R, Hall, RA, Harty, BL, Kirchhoff, C, Knapp, B, Krishnan, A, Liebscher, I, Lin, HH, Martinelli, DC, Monk, KR, Peeters, MC, Piao, X, Prömel, S, Schöneberg, T, Schwartz, TW, Singer, K, Stacey, M, Ushkaryov, YA, Vallon, M, Wolfrum, U, Wright, MW, Xu, L, Langenhan, T & Schiöth, HB 2015, 'International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors', Pharmacological Reviews, vol. 67, no. 2, pp. 338-367. https://doi.org/10.1124/pr.114.009647

TY - JOUR

T1 - International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors

AU - Hamann, Jörg

AU - Aust, Gabriela

AU - Araç, Demet

AU - Engel, Felix B.

AU - Formstone, Caroline

AU - Fredriksson, Robert

AU - Hall, Randy A.

AU - Harty, Breanne L.

AU - Kirchhoff, Christiane

AU - Knapp, Barbara

AU - Krishnan, Arunkumar

AU - Liebscher, Ines

AU - Lin, Hsi Hsien

AU - Martinelli, David C.

AU - Monk, Kelly R.

AU - Peeters, Miriam C.

AU - Piao, Xianhua

AU - Prömel, Simone

AU - Schöneberg, Torsten

AU - Schwartz, Thue W.

AU - Singer, Kathleen

AU - Stacey, Martin

AU - Ushkaryov, Yuri A.

AU - Vallon, Mario

AU - Wolfrum, Uwe

AU - Wright, Mathew W.

AU - Xu, Lei

AU - Langenhan, Tobias

AU - Schiöth, Helgi B.

PY - 2015/2/23

Y1 - 2015/2/23

N2 - The Adhesion family forms a large branch of the pharmacologically important super-family of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

AB - The Adhesion family forms a large branch of the pharmacologically important super-family of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

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DO - 10.1124/pr.114.009647

M3 - 文章

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SN - 0031-6997

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EP - 367

JO - Pharmacological Reviews

JF - Pharmacological Reviews

IS - 2

ER -

International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors

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