Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy: A rat embolic model

Yunn Hwa Ma; Ya Wun Hsu; Yeu Jhy Chang; Mu Yi Hua; Jyh Ping Chen; Tony Wu

doi:10.1016/j.jmmm.2006.10.1204

Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy: A rat embolic model

Yunn Hwa Ma, Ya Wun Hsu, Yeu Jhy Chang, Mu Yi Hua, Jyh Ping Chen, Tony Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

33 Scopus citations

Abstract

Targeted delivery of thrombolytic drug to the site of emboli exhibits potential to greatly reduce hemorrhagic side effect. A rat embolic model with an easy access of a magnet was established for study of the efficacy of magnetic drug targeting. In anesthetized rats, a whole blood clot produced in vitro was injected from the right iliac artery and lodged in the left iliac artery. Intra-arterial infusion of recombinant tissue plasminogen activator (rt-PA) thereafter significantly reversed the iliac flow within 15 min. Placement of an NdFeB magnet above the left iliac artery caused magnetic nanoparticle retention against hemodynamic dragging force in the presence and absence of the clot. Our results suggest the feasibility of this rat embolic model for the study of magnetic targeted delivery of thrombolytic drugs.

Original language	English
Pages (from-to)	342-346
Number of pages	5
Journal	Journal of Magnetism and Magnetic Materials
Volume	311
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jmmm.2006.10.1204
State	Published - 04 2007

Keywords

Magnetic nanoparticle
Nanomedicine
Targeted drug delivery
Thromboembolic disease
Thrombolysis
Tissue plasminogen activator

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10.1016/j.jmmm.2006.10.1204

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title = "Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy: A rat embolic model",

abstract = "Targeted delivery of thrombolytic drug to the site of emboli exhibits potential to greatly reduce hemorrhagic side effect. A rat embolic model with an easy access of a magnet was established for study of the efficacy of magnetic drug targeting. In anesthetized rats, a whole blood clot produced in vitro was injected from the right iliac artery and lodged in the left iliac artery. Intra-arterial infusion of recombinant tissue plasminogen activator (rt-PA) thereafter significantly reversed the iliac flow within 15 min. Placement of an NdFeB magnet above the left iliac artery caused magnetic nanoparticle retention against hemodynamic dragging force in the presence and absence of the clot. Our results suggest the feasibility of this rat embolic model for the study of magnetic targeted delivery of thrombolytic drugs.",

keywords = "Magnetic nanoparticle, Nanomedicine, Targeted drug delivery, Thromboembolic disease, Thrombolysis, Tissue plasminogen activator",

author = "Ma, {Yunn Hwa} and Hsu, {Ya Wun} and Chang, {Yeu Jhy} and Hua, {Mu Yi} and Chen, {Jyh Ping} and Tony Wu",

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doi = "10.1016/j.jmmm.2006.10.1204",

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T1 - Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy

T2 - A rat embolic model

AU - Ma, Yunn Hwa

AU - Hsu, Ya Wun

AU - Chang, Yeu Jhy

AU - Hua, Mu Yi

AU - Chen, Jyh Ping

AU - Wu, Tony

PY - 2007/4

Y1 - 2007/4

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AB - Targeted delivery of thrombolytic drug to the site of emboli exhibits potential to greatly reduce hemorrhagic side effect. A rat embolic model with an easy access of a magnet was established for study of the efficacy of magnetic drug targeting. In anesthetized rats, a whole blood clot produced in vitro was injected from the right iliac artery and lodged in the left iliac artery. Intra-arterial infusion of recombinant tissue plasminogen activator (rt-PA) thereafter significantly reversed the iliac flow within 15 min. Placement of an NdFeB magnet above the left iliac artery caused magnetic nanoparticle retention against hemodynamic dragging force in the presence and absence of the clot. Our results suggest the feasibility of this rat embolic model for the study of magnetic targeted delivery of thrombolytic drugs.

KW - Magnetic nanoparticle

KW - Nanomedicine

KW - Targeted drug delivery

KW - Thromboembolic disease

KW - Thrombolysis

KW - Tissue plasminogen activator

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DO - 10.1016/j.jmmm.2006.10.1204

M3 - 文章

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JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 1 SPEC. ISS.

ER -

Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy: A rat embolic model

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Keywords

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