Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system

Peter Brian Andersson*, V. Hugh Perry, Siamon Gordon

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

150 Scopus citations

Abstract

Neither excitotoxic neurodegeneration nor lipopolysaccharide induces an acute myelomonocytic exudate in the murine central nervous system (CNS) parenchyma (Andersson, P.-B., V. H. Perry, and S. Gordon. 1991. Neuroscience. 42:201; Andersson, P.-B., V. H. Perry, and S. Gordon. 1992. Neuroscience. 48:169). In this study formyl-methionyl-leucyl-phenylalanine, platelet-activating factor, interleukin 8 (IL-8), IL-1, or tumor necrosis factor α were injected into the hippocampus to assess whether these leukocyte chemotaxins and known mediators of recruitment could bypass this block. They induced morphologic activation of microglia and widespread leukocyte margination but little or no cell exudation into the CNS parenchyma. By contrast, there was acute myelomonocytic cell recruitment to the choroid plexus, meninges, and ventricular system, comparable to that in the skin after subcutaneous injection. The normal CNS parenchyma appears to be a tissue unique in its resistance to leukocyte diapedesis, which is shown here to be at a step beyond chemotactic cytokine secretion or induction of leukocyte adhesion to cerebral endothelium.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalJournal of Experimental Medicine
Volume176
Issue number1
StatePublished - 01 07 1992
Externally publishedYes

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