Intravascular Large B-cell lymphoma: A case series and review of literatures

Yuen Chin Ong, Hsiao Wen Kao, Wen Yu Chuang, Yu Shin Hung, Tung Liang Lin, Hung Chang, Ming Chung Kuo*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations


Background: Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin lymphoma with uncommon clinical presentations and poor prognosis. The purpose of this study is to report the clinical features and outcome of IVLBCL in a single institution of Taiwan. Methods: Ten patients with IVLBCL diagnosed from June 2006 to January 2018 were retrospectively reviewed. Results: The median age was 61 (range 39–88) years. The most common presentation was fever (90%), cytopenia (90%), and confusion (50%). For all patients, the median progression free survival (PFS) and overall survival (OS) were 12.6 (95% confidence interval [CI] 0.0–76.1) and 18.8 (95% CI 0–59.3) months, respectively. Six patients received rituximab combined chemotherapy, and the other one patient was treated with chemotherapy alone. Six of seven (85.7%) patients achieved complete response after chemotherapy. The median PFS and OS for six patients who completed treatment were not reached. Three-year PFS and OS rates were 80% and 75%, respectively. Conclusion: Our study showed that patients might achieve durable remission after rituximab-based chemotherapy. The outcome of IVLBCL patients may further improve if early diagnosis and prompt treatment were made.

Original languageEnglish
Pages (from-to)479-488
Number of pages10
JournalBiomedical Journal
Issue number4
StatePublished - 08 2021

Bibliographical note

Publisher Copyright:
© 2020 Chang Gung University


  • Hemophagocytosis
  • Intravascular large B-Cell lymphoma
  • Rituximab


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