Intravenous immunoglobulin, pharmacogenomics, and Kawasaki disease

Ho Chang Kuo, Yu Wen Hsu, Mei Shin Wu, Shu Chen Chien, Shih Feng Liu, Wei Chiao Chang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Kawasaki disease (KD) is a systemic vasculitis of unknown etiology and it is therefore worth examining the multifactorial interaction of genes and environmental factors. Targeted genetic association and genome-wide association studies have helped to provide a better understanding of KD from infection to the immune-related response. Findings in the past decade have contributed to a major breakthrough in the genetics of KD, with the identification of several genomic regions linked to the pathogenesis of KD, including ITPKC, CD40, BLK, and FCGR2A. This review focuses on the factors associated with the genetic polymorphisms of KD and the pharmacogenomics of the response to treatment in patients with intravenous immunoglobulin resistance.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Microbiology, Immunology and Infection
Issue number1
StatePublished - 01 02 2016

Bibliographical note

Publisher Copyright:
© 2014.


  • Genetic polymorphisms
  • Genome-wide association studies
  • Intravenous immunoglobulin resistance
  • Kawasaki disease
  • Pharmacogenomics


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