@inproceedings{9f5091e033f3446e8c827b44fd874a9b,
title = "Investigation of the Effect of Acoustic Pressure and Sonication Duration on Focused-Ultrasound Induced Blood-Brain Barrier Disruption",
abstract = "The purpose of this study is to investigate the influence of the ultrasound peak pressure and sonication duration on blood-brain barrier (BBB) disruption, and also seek for the optimized sonication parameter to introduce BBB-opening with minimal hemorrhagic damage. Twelve SD rats were sonicated. During sonication, the 309 kHz focused ultrasound was employed to deliver burst-mode low-pressure ultrasound to animal brains in the presence of microbubbles to introduce local and temporal BBB disruption. Different ultrasonic peak pressures and sonication durations were tested, and the BBB-disruption and accompanied hemorrhage were confirmed by brain section and histological examinations. Our results showed that the peak pressure is the major factor to generate BBB disruption, where as the sonication duration can be utilized to moderately regulate the accompanied hemorrhagic damage. We also found that the low-pressure long-duration ultrasound exposure may be beneficiary to reduce hemorrhage than high-pressure short-duration mode.",
keywords = "Focused ultrasound, blood-brain barrier, histology",
author = "Chu, {P. C.} and Hsiao, {M. C.} and Yang, {Y. H.} and Chen, {J. C.} and Liu, {H. L.}",
year = "2009",
doi = "10.1007/978-3-540-92841-6_269",
language = "英语",
isbn = "9783540928409",
series = "IFMBE Proceedings",
pages = "1094--1097",
booktitle = "13th International Conference on Biomedical Engineering - ICBME 2008",
note = "13th International Conference on Biomedical Engineering, ICBME 2008 ; Conference date: 03-12-2008 Through 06-12-2008",
}