Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUVmax of FDG-PET scan in esophageal squamous cell carcinoma

Chen Sung Lin; Yu Yi Huang; Siao Cian Pan; Chih Tao Cheng; Chia Chuan Liu; Chih Hsun Shih; Hsiang Ling Ho; Yi Chen Yeh; Teh Ying Chou; Ming Yuan Lee; Yau Huei Wei

doi:10.1016/j.mito.2019.05.001

Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUV_max of FDG-PET scan in esophageal squamous cell carcinoma

Chen Sung Lin
, Yu Yi Huang
, Siao Cian Pan
, Chih Tao Cheng
, Chia Chuan Liu
, Chih Hsun Shih
, Hsiang Ling Ho
, Yi Chen Yeh
, Teh Ying Chou
, Ming Yuan Lee
, Yau Huei Wei^*

^*Corresponding author for this work

Kainan University
National Taiwan Normal University
National Yang Ming Chiao Tung University
Taipei Hospital
Koo Foundation Sun Yat-Sen Cancer Center
Changhua Christian Hospital
Veterans General Hospital-Taipei

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUV_max) of ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNA^ESCC copy number (p < .05) but higher SUV_max-ESCC (p < .05), respectively. Lower mtDNA^ESCC copy number correlated with higher SUV_max-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNA^ESCC copy number (p = .056) but higher SUV_max-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.

Original language	English
Pages (from-to)	54-63
Number of pages	10
Journal	Mitochondrion
Volume	47
DOIs	https://doi.org/10.1016/j.mito.2019.05.001
State	Published - 07 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V. and Mitochondria Research Society

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Esophageal squamous cell carcinoma (ESCC)
F-fluorodeoxyglucose positron emission tomography (FDG-PET)
Maximum standard uptake value (SUV)
Mitochondrial DNA (mtDNA) copy number
Warburg effect
p53

Access to Document

10.1016/j.mito.2019.05.001

Cite this

Lin, C. S., Huang, Y. Y., Pan, S. C., Cheng, C. T., Liu, C. C., Shih, C. H., Ho, H. L., Yeh, Y. C., Chou, T. Y., Lee, M. Y., & Wei, Y. H. (2019). Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUV_max of FDG-PET scan in esophageal squamous cell carcinoma. Mitochondrion, 47, 54-63. https://doi.org/10.1016/j.mito.2019.05.001

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title = "Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUVmax of FDG-PET scan in esophageal squamous cell carcinoma",

abstract = "We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNAESCC copy number (p < .05) but higher SUVmax-ESCC (p < .05), respectively. Lower mtDNAESCC copy number correlated with higher SUVmax-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNAESCC copy number (p = .056) but higher SUVmax-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.",

keywords = "Esophageal squamous cell carcinoma (ESCC), F-fluorodeoxyglucose positron emission tomography (FDG-PET), Maximum standard uptake value (SUV), Mitochondrial DNA (mtDNA) copy number, Warburg effect, p53",

author = "Lin, \{Chen Sung\} and Huang, \{Yu Yi\} and Pan, \{Siao Cian\} and Cheng, \{Chih Tao\} and Liu, \{Chia Chuan\} and Shih, \{Chih Hsun\} and Ho, \{Hsiang Ling\} and Yeh, \{Yi Chen\} and Chou, \{Teh Ying\} and Lee, \{Ming Yuan\} and Wei, \{Yau Huei\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V. and Mitochondria Research Society",

year = "2019",

month = jul,

doi = "10.1016/j.mito.2019.05.001",

language = "英语",

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T1 - Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUVmax of FDG-PET scan in esophageal squamous cell carcinoma

AU - Lin, Chen Sung

AU - Huang, Yu Yi

AU - Pan, Siao Cian

AU - Cheng, Chih Tao

AU - Liu, Chia Chuan

AU - Shih, Chih Hsun

AU - Ho, Hsiang Ling

AU - Yeh, Yi Chen

AU - Chou, Teh Ying

AU - Lee, Ming Yuan

AU - Wei, Yau Huei

PY - 2019/7

Y1 - 2019/7

N2 - We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNAESCC copy number (p < .05) but higher SUVmax-ESCC (p < .05), respectively. Lower mtDNAESCC copy number correlated with higher SUVmax-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNAESCC copy number (p = .056) but higher SUVmax-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.

AB - We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNAESCC copy number (p < .05) but higher SUVmax-ESCC (p < .05), respectively. Lower mtDNAESCC copy number correlated with higher SUVmax-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNAESCC copy number (p = .056) but higher SUVmax-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.

KW - Esophageal squamous cell carcinoma (ESCC)

KW - F-fluorodeoxyglucose positron emission tomography (FDG-PET)

KW - Maximum standard uptake value (SUV)

KW - Mitochondrial DNA (mtDNA) copy number

KW - Warburg effect

KW - p53

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U2 - 10.1016/j.mito.2019.05.001

DO - 10.1016/j.mito.2019.05.001

M3 - 文章

C2 - 31071450

AN - SCOPUS:85065601001

SN - 1567-7249

VL - 47

SP - 54

EP - 63

JO - Mitochondrion

JF - Mitochondrion

ER -