Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

Shiow Chyn Huang; Ping Chung Kuo; Hsin Yi Hung; Tai Long Pan; Fu An Chen; Tian Shung Wu

doi:10.3390/ijms17050681

Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

Shiow Chyn Huang, Ping Chung Kuo, Hsin Yi Hung, Tai Long Pan, Fu An Chen, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Letter › peer-review

17 Scopus citations

Abstract

Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

Original language	English
Article number	681
Journal	International Journal of Molecular Sciences
Volume	17
Issue number	5
DOIs	https://doi.org/10.3390/ijms17050681
State	Published - 06 05 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

Fungus
Hepatic fibrosis
Ionone
Phellinulin
Phellinus linteus

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title = "Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells",

abstract = "Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.",

keywords = "Fungus, Hepatic fibrosis, Ionone, Phellinulin, Phellinus linteus",

author = "Huang, \{Shiow Chyn\} and Kuo, \{Ping Chung\} and Hung, \{Hsin Yi\} and Pan, \{Tai Long\} and Chen, \{Fu An\} and Wu, \{Tian Shung\}",

note = "Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2016",

month = may,

day = "6",

doi = "10.3390/ijms17050681",

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T1 - Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

AU - Huang, Shiow Chyn

AU - Kuo, Ping Chung

AU - Hung, Hsin Yi

AU - Pan, Tai Long

AU - Chen, Fu An

AU - Wu, Tian Shung

PY - 2016/5/6

Y1 - 2016/5/6

N2 - Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

AB - Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

KW - Fungus

KW - Hepatic fibrosis

KW - Ionone

KW - Phellinulin

KW - Phellinus linteus

UR - https://www.scopus.com/pages/publications/84966440371

U2 - 10.3390/ijms17050681

DO - 10.3390/ijms17050681

M3 - 快报

C2 - 27164091

AN - SCOPUS:84966440371

SN - 1661-6596

VL - 17

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 5

M1 - 681

ER -

Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

Abstract

Bibliographical note

Keywords

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