Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

Iou Jiun Kang; Li Wen Wang; Tsu An Hsu; Andrew Yueh; Chung Chi Lee; Yen Chun Lee; Ching Yin Lee; Yu Sheng Chao; Shin Ru Shih; Jyh Haur Chern

doi:10.1016/j.bmcl.2011.02.037

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

Iou Jiun Kang, Li Wen Wang, Tsu An Hsu, Andrew Yueh, Chung Chi Lee, Yen Chun Lee, Ching Yin Lee, Yu Sheng Chao, Shin Ru Shih^*, Jyh Haur Chern

^*Corresponding author for this work

Department of Medical Biotechnology and Laboratory Science

Research output: Contribution to journal › Journal Article › peer-review

66 Scopus citations

Abstract

A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

Original language	English
Pages (from-to)	1948-1952
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2011.02.037
State	Published - 01 04 2011

Keywords

HSV-1
HSV-2
Herpes simplex virus

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10.1016/j.bmcl.2011.02.037

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title = "Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors",

abstract = "A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.",

keywords = "HSV-1, HSV-2, Herpes simplex virus",

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AU - Kang, Iou Jiun

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AU - Hsu, Tsu An

AU - Yueh, Andrew

AU - Lee, Chung Chi

AU - Lee, Yen Chun

AU - Lee, Ching Yin

AU - Chao, Yu Sheng

AU - Shih, Shin Ru

AU - Chern, Jyh Haur

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N2 - A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

AB - A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

KW - HSV-1

KW - HSV-2

KW - Herpes simplex virus

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SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

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Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

Abstract

Keywords

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