Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

Iou Jiun Kang, Li Wen Wang, Tsu An Hsu, Andrew Yueh, Chung Chi Lee, Yen Chun Lee, Ching Yin Lee, Yu Sheng Chao, Shin Ru Shih*, Jyh Haur Chern

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

62 Scopus citations

Abstract

A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

Original languageEnglish
Pages (from-to)1948-1952
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number7
DOIs
StatePublished - 01 04 2011

Keywords

  • HSV-1
  • HSV-2
  • Herpes simplex virus

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