Abstract
腎臟的類澱粉症是由於不溶的蛋白纖維積聚在腎臟所造成。這些蛋白纖維堆積會造成腎臟結構及功能的改變。大部分腎臟的類澱粉症是來自骨髓癌。一位71歲男性因雙側腳腫及蛋白尿住院，從血清及尿液的蛋白質電泳及免疫固定電泳分析顯示出有單株k輕鏈蛋白病變。骨髓切片並沒有發現到漿細胞數目的增加，但是免疫過氧化?染色則只有k輕鏈型蛋白合成。腎臟病理切片診斷為腎臟類澱粉症。此病例顯示腎臟的類澱粉症也可來自單獨的單株免疫球蛋白病變。
Renal amyloidosis is a disease caused by accumulation of insoluble protein fibrils in the kidneys. Accumulation of these fibrils in the kidneys progressively disrupts renal structure and function. Renal amyloidosis is frequently associated with myeloma. This article describes a 71-year-old male who presented with bilateral leg edema and nephrotic proteinuria. Monoclonal kappa light chain was identified by immunofixation electrophoresis and protein electrophoresis analysis of blood and urine. Bone marrow biopsy showed no plasma cell increase, but immunoperoxidase staining revealed only monoclonal kappa light chain. Renal biopsy revealed renal amyloidosis. The specific presentation in this patient demonstrates that renal amyloidosis can develop in patients with isolated monoclonal gammopathy.
Renal amyloidosis is a disease caused by accumulation of insoluble protein fibrils in the kidneys. Accumulation of these fibrils in the kidneys progressively disrupts renal structure and function. Renal amyloidosis is frequently associated with myeloma. This article describes a 71-year-old male who presented with bilateral leg edema and nephrotic proteinuria. Monoclonal kappa light chain was identified by immunofixation electrophoresis and protein electrophoresis analysis of blood and urine. Bone marrow biopsy showed no plasma cell increase, but immunoperoxidase staining revealed only monoclonal kappa light chain. Renal biopsy revealed renal amyloidosis. The specific presentation in this patient demonstrates that renal amyloidosis can develop in patients with isolated monoclonal gammopathy.
| Original language | American English |
|---|---|
| Pages (from-to) | 65 |
| Journal | 臺灣腎臟醫學會雜誌 |
| Volume | 21 |
| Issue number | 1 |
| State | Published - 2007 |