Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia

Li Guo Zheng; You Yan Chen; Chia Ching Liaw; Yu Chi Lin; Su Ying Chien; Yi Hao Lo; Yu Chi Tsai; Hao Chun Hu; You Ying Chen; Tsong Long Hwang; Tzu Ming Ou; Ping Jyun Sung

doi:10.1016/j.phytol.2024.04.013

Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia

Li Guo Zheng, You Yan Chen, Chia Ching Liaw, Yu Chi Lin, Su Ying Chien, Yi Hao Lo, Yu Chi Tsai, Hao Chun Hu, You Ying Chen, Tsong Long Hwang, Tzu Ming Ou^*, Ping Jyun Sung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

Abstract

The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Phytochemistry Letters
Volume	61
DOIs	https://doi.org/10.1016/j.phytol.2024.04.013
State	Published - 06 2024

Bibliographical note

Publisher Copyright:
© 2024 Phytochemical Society of Europe

Keywords

Felixin
Homoscalarane
Lendenfeldarane
Lendenfeldia
MG63

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2024.04.013

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@article{052a220a8edb47c0a856f06e77b10d41,

title = "Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia",

abstract = "The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells.",

keywords = "Felixin, Homoscalarane, Lendenfeldarane, Lendenfeldia, MG63",

author = "Zheng, {Li Guo} and Chen, {You Yan} and Liaw, {Chia Ching} and Lin, {Yu Chi} and Chien, {Su Ying} and Lo, {Yi Hao} and Tsai, {Yu Chi} and Hu, {Hao Chun} and Chen, {You Ying} and Hwang, {Tsong Long} and Ou, {Tzu Ming} and Sung, {Ping Jyun}",

note = "Publisher Copyright: {\textcopyright} 2024 Phytochemical Society of Europe",

year = "2024",

month = jun,

doi = "10.1016/j.phytol.2024.04.013",

language = "英语",

volume = "61",

pages = "177--181",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia

AU - Zheng, Li Guo

AU - Chen, You Yan

AU - Liaw, Chia Ching

AU - Lin, Yu Chi

AU - Chien, Su Ying

AU - Lo, Yi Hao

AU - Tsai, Yu Chi

AU - Hu, Hao Chun

AU - Chen, You Ying

AU - Hwang, Tsong Long

AU - Ou, Tzu Ming

AU - Sung, Ping Jyun

PY - 2024/6

Y1 - 2024/6

N2 - The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells.

AB - The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells.

KW - Felixin

KW - Homoscalarane

KW - Lendenfeldarane

KW - Lendenfeldia

KW - MG63

UR - http://www.scopus.com/inward/record.url?scp=85191335281&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2024.04.013

DO - 10.1016/j.phytol.2024.04.013

M3 - 文章

AN - SCOPUS:85191335281

SN - 1874-3900

VL - 61

SP - 177

EP - 181

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia

Abstract

Bibliographical note

Keywords

UN SDGs

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