Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei Chuan Chen; Guei Jane Wang; Yueh Hsiung Kuo; Yin Ru Chiang; Ting Yu Cho; Yu Ming Ju; Tzong Huei Lee

doi:10.1016/j.jfda.2018.05.007

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei Chuan Chen, Guei Jane Wang, Yueh Hsiung Kuo, Yin Ru Chiang, Ting Yu Cho, Yu Ming Ju, Tzong Huei Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E_max values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

Original language	English
Pages (from-to)	111-117
Number of pages	7
Journal	Journal of Food and Drug Analysis
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.jfda.2018.05.007
State	Published - 01 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018

Keywords

Anti-inflammation
Fimbriether
Isoprenyl phenolic ether
Nitric oxide inhibition
Xylaria fimbriata

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10.1016/j.jfda.2018.05.007

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title = "Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata",

abstract = "Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.",

keywords = "Anti-inflammation, Fimbriether, Isoprenyl phenolic ether, Nitric oxide inhibition, Xylaria fimbriata",

author = "Chen, {Mei Chuan} and Wang, {Guei Jane} and Kuo, {Yueh Hsiung} and Chiang, {Yin Ru} and Cho, {Ting Yu} and Ju, {Yu Ming} and Lee, {Tzong Huei}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = jan,

doi = "10.1016/j.jfda.2018.05.007",

language = "英语",

volume = "27",

pages = "111--117",

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AU - Chen, Mei Chuan

AU - Wang, Guei Jane

AU - Kuo, Yueh Hsiung

AU - Chiang, Yin Ru

AU - Cho, Ting Yu

AU - Ju, Yu Ming

AU - Lee, Tzong Huei

PY - 2019/1

Y1 - 2019/1

N2 - Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

AB - Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

KW - Anti-inflammation

KW - Fimbriether

KW - Isoprenyl phenolic ether

KW - Nitric oxide inhibition

KW - Xylaria fimbriata

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U2 - 10.1016/j.jfda.2018.05.007

DO - 10.1016/j.jfda.2018.05.007

M3 - 文章

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AN - SCOPUS:85048854588

SN - 1021-9498

VL - 27

SP - 111

EP - 117

JO - Journal of Food and Drug Analysis

JF - Journal of Food and Drug Analysis

IS - 1

ER -

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Abstract

Bibliographical note

Keywords

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