Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

Ho Chang Kuo; Kuender D. Yang; Suh Hang Hank Juo; Chi Di Liang; Wei Chiao Chen; Yu Shiuan Wang; Chih Hung Lee; Edward Hsi; Hong Ren Yu; Peng Yeong Woon; I. Chun Lin; Chien Fu Huang; Daw Yang Hwang; Chiu Ping Lee; Li Yan Lin; Wei Pin Chang; Wei Chiao Chang

doi:10.1371/journal.pone.0017370

Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

Ho Chang Kuo, Kuender D. Yang, Suh Hang Hank Juo, Chi Di Liang, Wei Chiao Chen, Yu Shiuan Wang, Chih Hung Lee, Edward Hsi, Hong Ren Yu, Peng Yeong Woon, I. Chun Lin, Chien Fu Huang, Daw Yang Hwang, Chiu Ping Lee, Li Yan Lin, Wei Pin Chang^*, Wei Chiao Chang

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

81 Scopus citations

Abstract

Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

Original language	English
Article number	e17370
Journal	PLoS ONE
Volume	6
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0017370
State	Published - 2011

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Kuo, H. C., Yang, K. D., Juo, S. H. H., Liang, C. D., Chen, W. C., Wang, Y. S., Lee, C. H., Hsi, E., Yu, H. R., Woon, P. Y., Lin, I. C., Huang, C. F., Hwang, D. Y., Lee, C. P., Lin, L. Y., Chang, W. P., & Chang, W. C. (2011). Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population. PLoS ONE, 6(4), Article e17370. https://doi.org/10.1371/journal.pone.0017370

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title = "Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population",

abstract = "Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.",

author = "Kuo, {Ho Chang} and Yang, {Kuender D.} and Juo, {Suh Hang Hank} and Liang, {Chi Di} and Chen, {Wei Chiao} and Wang, {Yu Shiuan} and Lee, {Chih Hung} and Edward Hsi and Yu, {Hong Ren} and Woon, {Peng Yeong} and Lin, {I. Chun} and Huang, {Chien Fu} and Hwang, {Daw Yang} and Lee, {Chiu Ping} and Lin, {Li Yan} and Chang, {Wei Pin} and Chang, {Wei Chiao}",

year = "2011",

doi = "10.1371/journal.pone.0017370",

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journal = "PLoS ONE",

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T1 - Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

AU - Kuo, Ho Chang

AU - Yang, Kuender D.

AU - Juo, Suh Hang Hank

AU - Liang, Chi Di

AU - Chen, Wei Chiao

AU - Wang, Yu Shiuan

AU - Lee, Chih Hung

AU - Hsi, Edward

AU - Yu, Hong Ren

AU - Woon, Peng Yeong

AU - Lin, I. Chun

AU - Huang, Chien Fu

AU - Hwang, Daw Yang

AU - Lee, Chiu Ping

AU - Lin, Li Yan

AU - Chang, Wei Pin

AU - Chang, Wei Chiao

PY - 2011

Y1 - 2011

N2 - Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

AB - Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

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U2 - 10.1371/journal.pone.0017370

DO - 10.1371/journal.pone.0017370

M3 - 文章

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AN - SCOPUS:79955018203

SN - 1932-6203

VL - 6

JO - PLoS ONE

JF - PLoS ONE

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M1 - e17370

ER -

Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

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