Ixorapeptide i and ixorapeptide II, bioactive peptides isolated from Ixora coccinea

Chia Lin Lee; Yung Chih Liao; Tsong Long Hwang; Chin Chung Wu; Fang Rong Chang; Yang Chang Wu

doi:10.1016/j.bmcl.2010.10.058

Ixorapeptide i and ixorapeptide II, bioactive peptides isolated from Ixora coccinea

Chia Lin Lee
, Yung Chih Liao
, Tsong Long Hwang
, Chin Chung Wu
, Fang Rong Chang^*
, Yang Chang Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

31 Scopus citations

Abstract

Two novel derivatized peptides, designated as ixorapeptide I (1) and ixorapeptide II (2), in addition to 28 other known compounds, were isolated from the MeOH extract of Ixora coccinea using bioassay-guided fractionation. The structures of metabolites 1 and 2 were determined by interpretation of the spectroscopic data and Marfey's method. Compound 1 exhibited selective potency against Hep3B liver cancer cell line with an IC₅₀ value of 3.36 μg/mL, and compound 2 did not show notable cytotoxicity toward cancer cell lines but could inhibit superoxide anion generation and elastase release with IC₅₀ values of 0.21 and 0.27 μg/mL, respectively. Moreover, kaempferol and luteolin from this plant showed inhibition with IC₅₀ values of 3.55 and 2.56 μg/mL, respectively on platelet aggregation induced by collagen.

Original language	English
Pages (from-to)	7354-7357
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2010.10.058
State	Published - 15 12 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-cytotoxicity
Anti-inflammation
Anti-platelet aggregation
Ixora coccinea
Ixorapeptide I
Ixorapeptide II
Rubiaceae

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10.1016/j.bmcl.2010.10.058

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title = "Ixorapeptide i and ixorapeptide II, bioactive peptides isolated from Ixora coccinea",

abstract = "Two novel derivatized peptides, designated as ixorapeptide I (1) and ixorapeptide II (2), in addition to 28 other known compounds, were isolated from the MeOH extract of Ixora coccinea using bioassay-guided fractionation. The structures of metabolites 1 and 2 were determined by interpretation of the spectroscopic data and Marfey's method. Compound 1 exhibited selective potency against Hep3B liver cancer cell line with an IC50 value of 3.36 μg/mL, and compound 2 did not show notable cytotoxicity toward cancer cell lines but could inhibit superoxide anion generation and elastase release with IC50 values of 0.21 and 0.27 μg/mL, respectively. Moreover, kaempferol and luteolin from this plant showed inhibition with IC50 values of 3.55 and 2.56 μg/mL, respectively on platelet aggregation induced by collagen.",

keywords = "Anti-cytotoxicity, Anti-inflammation, Anti-platelet aggregation, Ixora coccinea, Ixorapeptide I, Ixorapeptide II, Rubiaceae",

author = "Lee, \{Chia Lin\} and Liao, \{Yung Chih\} and Hwang, \{Tsong Long\} and Wu, \{Chin Chung\} and Chang, \{Fang Rong\} and Wu, \{Yang Chang\}",

year = "2010",

month = dec,

day = "15",

doi = "10.1016/j.bmcl.2010.10.058",

language = "英语",

volume = "20",

pages = "7354--7357",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

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T1 - Ixorapeptide i and ixorapeptide II, bioactive peptides isolated from Ixora coccinea

AU - Lee, Chia Lin

AU - Liao, Yung Chih

AU - Hwang, Tsong Long

AU - Wu, Chin Chung

AU - Chang, Fang Rong

AU - Wu, Yang Chang

PY - 2010/12/15

Y1 - 2010/12/15

N2 - Two novel derivatized peptides, designated as ixorapeptide I (1) and ixorapeptide II (2), in addition to 28 other known compounds, were isolated from the MeOH extract of Ixora coccinea using bioassay-guided fractionation. The structures of metabolites 1 and 2 were determined by interpretation of the spectroscopic data and Marfey's method. Compound 1 exhibited selective potency against Hep3B liver cancer cell line with an IC50 value of 3.36 μg/mL, and compound 2 did not show notable cytotoxicity toward cancer cell lines but could inhibit superoxide anion generation and elastase release with IC50 values of 0.21 and 0.27 μg/mL, respectively. Moreover, kaempferol and luteolin from this plant showed inhibition with IC50 values of 3.55 and 2.56 μg/mL, respectively on platelet aggregation induced by collagen.

AB - Two novel derivatized peptides, designated as ixorapeptide I (1) and ixorapeptide II (2), in addition to 28 other known compounds, were isolated from the MeOH extract of Ixora coccinea using bioassay-guided fractionation. The structures of metabolites 1 and 2 were determined by interpretation of the spectroscopic data and Marfey's method. Compound 1 exhibited selective potency against Hep3B liver cancer cell line with an IC50 value of 3.36 μg/mL, and compound 2 did not show notable cytotoxicity toward cancer cell lines but could inhibit superoxide anion generation and elastase release with IC50 values of 0.21 and 0.27 μg/mL, respectively. Moreover, kaempferol and luteolin from this plant showed inhibition with IC50 values of 3.55 and 2.56 μg/mL, respectively on platelet aggregation induced by collagen.

KW - Anti-cytotoxicity

KW - Anti-inflammation

KW - Anti-platelet aggregation

KW - Ixora coccinea

KW - Ixorapeptide I

KW - Ixorapeptide II

KW - Rubiaceae

UR - https://www.scopus.com/pages/publications/78449282832

U2 - 10.1016/j.bmcl.2010.10.058

DO - 10.1016/j.bmcl.2010.10.058

M3 - 文章

C2 - 21106454

AN - SCOPUS:78449282832

SN - 0960-894X

VL - 20

SP - 7354

EP - 7357

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Ixorapeptide i and ixorapeptide II, bioactive peptides isolated from Ixora coccinea

Abstract

UN SDGs

Keywords

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