Junceellolides J-L, 11,20-epoxybriaranes from the gorgonian coral Junceella fragilis

Jyh Horng Sheu, Yu Pei Chen, Tsong Long Hwang, Michael Y. Chiang, Lee Shing Fang, Ping Jyun Sung*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

55 Scopus citations


Three new 11,20-epoxybriarane diterpenoids, junceellolides J-L (1-3), along with a known metabolite, 4, have been isolated from the gorgonian coral Junceella fragilis. The structures of these metabolites were elucidated using spectroscopic methods. The cyclohexane rings were found to exist in boat form in briaranes 1 and 4 and in chair form in 2 and 3. The structure of 1 was further confirmed by chemical conversion and single-crystal X-ray diffraction analysis. The relationship between 13C NMR chemical shifts and the conformation of the cyclohexane ring in briaranes possessing an 11,20-epoxy group are described. The briaranes 2 and 4 showed mild inhibitory effects on human neutrophil elastase release.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalJournal of Natural Products
Issue number2
StatePublished - 02 2006


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