Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam

A. A. Moosavi-Movahedi, H. Sepassi Tehrani, M. Amanlou, M. N. Soltani Rad, G. H. Hakimelahi, F. Y. Tsai, G. Ataie, A. A. Saboury, F. Ahmad, A. Khalafi-Nezhad, N. Poursasan, A. Sharifizadeh

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalProtein and Peptide Letters
Volume17
Issue number2
DOIs
StatePublished - 2010

Keywords

  • Adenosine deaminase
  • Kinetics
  • Lorazepam
  • Oxazepam
  • Structures

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