Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam

A. A. Moosavi-Movahedi; H. Sepassi Tehrani; M. Amanlou; M. N. Soltani Rad; G. H. Hakimelahi; F. Y. Tsai; G. Ataie; A. A. Saboury; F. Ahmad; A. Khalafi-Nezhad; N. Poursasan; A. Sharifizadeh

doi:10.2174/092986610790226076

Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam

A. A. Moosavi-Movahedi
, H. Sepassi Tehrani
, M. Amanlou
, M. N. Soltani Rad
, G. H. Hakimelahi
, F. Y. Tsai
, G. Ataie
, A. A. Saboury
, F. Ahmad
, A. Khalafi-Nezhad
, N. Poursasan
, A. Sharifizadeh

Center for General Education

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

Original language	English
Pages (from-to)	197-205
Number of pages	9
Journal	Protein and Peptide Letters
Volume	17
Issue number	2
DOIs	https://doi.org/10.2174/092986610790226076
State	Published - 2010

Keywords

Adenosine deaminase
Kinetics
Lorazepam
Oxazepam
Structures

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Moosavi-Movahedi, A. A., Tehrani, H. S., Amanlou, M., Soltani Rad, M. N., Hakimelahi, G. H., Tsai, F. Y., Ataie, G., Saboury, A. A., Ahmad, F., Khalafi-Nezhad, A., Poursasan, N., & Sharifizadeh, A. (2010). Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam. Protein and Peptide Letters, 17(2), 197-205. https://doi.org/10.2174/092986610790226076

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title = "Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam",

abstract = "Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.",

keywords = "Adenosine deaminase, Kinetics, Lorazepam, Oxazepam, Structures",

author = "Moosavi-Movahedi, \{A. A.\} and Tehrani, \{H. Sepassi\} and M. Amanlou and \{Soltani Rad\}, \{M. N.\} and Hakimelahi, \{G. H.\} and Tsai, \{F. Y.\} and G. Ataie and Saboury, \{A. A.\} and F. Ahmad and A. Khalafi-Nezhad and N. Poursasan and A. Sharifizadeh",

year = "2010",

doi = "10.2174/092986610790226076",

language = "英语",

volume = "17",

pages = "197--205",

journal = "Protein and Peptide Letters",

issn = "0929-8665",

publisher = "Bentham Science Publishers",

number = "2",

}

Moosavi-Movahedi, AA, Tehrani, HS, Amanlou, M, Soltani Rad, MN, Hakimelahi, GH, Tsai, FY, Ataie, G, Saboury, AA, Ahmad, F, Khalafi-Nezhad, A, Poursasan, N & Sharifizadeh, A 2010, 'Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam', Protein and Peptide Letters, vol. 17, no. 2, pp. 197-205. https://doi.org/10.2174/092986610790226076

TY - JOUR

T1 - Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam

AU - Moosavi-Movahedi, A. A.

AU - Tehrani, H. Sepassi

AU - Amanlou, M.

AU - Soltani Rad, M. N.

AU - Hakimelahi, G. H.

AU - Tsai, F. Y.

AU - Ataie, G.

AU - Saboury, A. A.

AU - Ahmad, F.

AU - Khalafi-Nezhad, A.

AU - Poursasan, N.

AU - Sharifizadeh, A.

PY - 2010

Y1 - 2010

N2 - Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

AB - Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

KW - Adenosine deaminase

KW - Kinetics

KW - Lorazepam

KW - Oxazepam

KW - Structures

UR - https://www.scopus.com/pages/publications/77949956630

U2 - 10.2174/092986610790226076

DO - 10.2174/092986610790226076

M3 - 文章

C2 - 20214645

AN - SCOPUS:77949956630

SN - 0929-8665

VL - 17

SP - 197

EP - 205

JO - Protein and Peptide Letters

JF - Protein and Peptide Letters

IS - 2

ER -

Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam

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Keywords

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