Abstract
The kinetics of stereoselective esterification of racemic Naproxen with trimethylsilyl methanol by Candida cylindracea lipase in organic solvents has been investigated. A Ping-Pong Bi Bi mechanism with competitive inhibition by this alcohol for each enantiomer -has been identified. The rate equations were further analyzed in the time-course reaction after considering the effect of enzyme deactivation in the organic mixtures, but not in isooctane. Effects of the hydrophobicity of solvent on the solubility of the racemate, the kinetic parameters and their combinations are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 33-45 |
| Number of pages | 13 |
| Journal | Biocatalysis and Biotransformation |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
Keywords
- Esterification
- Lipase
- Naproxen
- Organic solvent
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