KLOTHO methylation is linked to uremic toxins and chronic kidney disease

Guang Huar Young; Vin Cent Wu

doi:10.1038/ki.2011.461

KLOTHO methylation is linked to uremic toxins and chronic kidney disease

Guang Huar Young
, Vin Cent Wu^*

^*Corresponding author for this work

National Taiwan University

Research output: Contribution to journal › Comment/debate

73 Scopus citations

Abstract

Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease (CKD) progression. The KLOTHO protein is a key modulator of homeostasis in renal function. Uremic toxin accumulation can induce DNA methyltransferase (DNMT) protein expression, which is involved in the silencing of KLOTHO through hypermethylation. Treatment with DNMT inhibitors can induce a hypermethylated status of KLOTHO and suppress mRNA and protein expression. Epigenetic targeting of specific genes may become an effective strategy to prevent progression of uremia-related CKD.

Original language	English
Pages (from-to)	611-612
Number of pages	2
Journal	Kidney International
Volume	81
Issue number	7
DOIs	https://doi.org/10.1038/ki.2011.461
State	Published - 01 04 2012
Externally published	Yes

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10.1038/ki.2011.461

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abstract = "Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease (CKD) progression. The KLOTHO protein is a key modulator of homeostasis in renal function. Uremic toxin accumulation can induce DNA methyltransferase (DNMT) protein expression, which is involved in the silencing of KLOTHO through hypermethylation. Treatment with DNMT inhibitors can induce a hypermethylated status of KLOTHO and suppress mRNA and protein expression. Epigenetic targeting of specific genes may become an effective strategy to prevent progression of uremia-related CKD.",

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AU - Wu, Vin Cent

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AB - Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease (CKD) progression. The KLOTHO protein is a key modulator of homeostasis in renal function. Uremic toxin accumulation can induce DNA methyltransferase (DNMT) protein expression, which is involved in the silencing of KLOTHO through hypermethylation. Treatment with DNMT inhibitors can induce a hypermethylated status of KLOTHO and suppress mRNA and protein expression. Epigenetic targeting of specific genes may become an effective strategy to prevent progression of uremia-related CKD.

UR - https://www.scopus.com/pages/publications/84858305531

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M3 - 评论/辩论

AN - SCOPUS:84858305531

SN - 0085-2538

VL - 81

SP - 611

EP - 612

JO - Kidney International

JF - Kidney International

IS - 7

ER -

KLOTHO methylation is linked to uremic toxins and chronic kidney disease

Abstract

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