Abstract
目的︰由慢性皰疹病毒造成單側腦部病變所表現出Kluver-Bucy症候群的個案是罕見的。病例報告︰本文報告一位三十八歲女性個案，其表現出不尋常的精神及行為上的異常，如失憶、僵直、人格改變、抽搐和Kluver-Bucy症候群達六個月之久。經一系列的腦部核磁共振影像檢查、脊髓液及血液皰疹病毒檢驗，高度懷疑這是一個慢性皰疹病毒僅造成單側腦部病變所表現出精神異常的罕見個案。經過Acyclovior及Carbamazepine治療後，個案的精神及行為異常有顯著改善，且能回復到原來的工作，再經兩年的追蹤，個案一切尚可，並無大礙。結論︰本報告顯示即使延遲診斷，這樣的個案亦有可能治療，不要輕言放棄。
Objectives: Reports of Kluver-Bucy syndrome due to a unilateral temporal lesion caused by chronic herpes simplex encephalitis (HSE) are rare. Case Report: Our patient was a 38-year-old woman with a 6-month history of progressive amnesia, catatonia, seizures, and Kluver-Bucy syndrome. The CT and T1-weighted MRI of the brain showed low density lesions in the left basal ganglion and temporal area. Serial antibody studies on her cerebrospinal fluid and serum showed an increasing titer of herpes simplex I. Her mental and behavior disturbances dramatically improved after treatment with acyclovior 1500 mg daily for ten days and subsequently, carbamazepine 600 mg daily and she was able to return to her job. During two years of follow-up, most of her mental function and behavior were within normal limits. Conclusion: It is possible that HSE can involve only a unilateral temporal lobe and the basal ganglion and then be expressed as Kluver-Bucy syndrome. The variable intellectual and psychiatric impairments are treatable even with a delayed diagnosis.
Objectives: Reports of Kluver-Bucy syndrome due to a unilateral temporal lesion caused by chronic herpes simplex encephalitis (HSE) are rare. Case Report: Our patient was a 38-year-old woman with a 6-month history of progressive amnesia, catatonia, seizures, and Kluver-Bucy syndrome. The CT and T1-weighted MRI of the brain showed low density lesions in the left basal ganglion and temporal area. Serial antibody studies on her cerebrospinal fluid and serum showed an increasing titer of herpes simplex I. Her mental and behavior disturbances dramatically improved after treatment with acyclovior 1500 mg daily for ten days and subsequently, carbamazepine 600 mg daily and she was able to return to her job. During two years of follow-up, most of her mental function and behavior were within normal limits. Conclusion: It is possible that HSE can involve only a unilateral temporal lobe and the basal ganglion and then be expressed as Kluver-Bucy syndrome. The variable intellectual and psychiatric impairments are treatable even with a delayed diagnosis.
| Original language | American English |
|---|---|
| Pages (from-to) | 80-86 |
| Journal | 臺灣精神醫學 |
| Volume | 11 |
| Issue number | 4 |
| State | Published - 1997 |