Klyflaccisteroids K–M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum

Yi Ying Tsai; Chiung Yao Huang; Wan Ru Tseng; Pei Lun Chiang; Tsong Long Hwang; Jui Hsin Su; Ping Jyun Sung; Chang Feng Dai; Jyh Horng Sheu

doi:10.1016/j.bmcl.2017.01.060

Klyflaccisteroids K–M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum

Yi Ying Tsai, Chiung Yao Huang, Wan Ru Tseng, Pei Lun Chiang, Tsong Long Hwang, Jui Hsin Su, Ping Jyun Sung, Chang Feng Dai, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

New steroids, klyflaccisteroids K–M (1–3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O₂ ⁻ ^[rad]) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.

Original language	English
Pages (from-to)	1220-1224
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2017.01.060
State	Published - 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

Anti-inflammatory activity
Cytotoxicity
Klyflaccisteroid
Klyxum flaccidum
Steroid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2017.01.060

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title = "Klyflaccisteroids K–M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum",

abstract = "New steroids, klyflaccisteroids K–M (1–3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2 − [rad]) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.",

keywords = "Anti-inflammatory activity, Cytotoxicity, Klyflaccisteroid, Klyxum flaccidum, Steroid",

author = "Tsai, {Yi Ying} and Huang, {Chiung Yao} and Tseng, {Wan Ru} and Chiang, {Pei Lun} and Hwang, {Tsong Long} and Su, {Jui Hsin} and Sung, {Ping Jyun} and Dai, {Chang Feng} and Sheu, {Jyh Horng}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2017.01.060",

language = "英语",

volume = "27",

pages = "1220--1224",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Klyflaccisteroids K–M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum

AU - Tsai, Yi Ying

AU - Huang, Chiung Yao

AU - Tseng, Wan Ru

AU - Chiang, Pei Lun

AU - Hwang, Tsong Long

AU - Su, Jui Hsin

AU - Sung, Ping Jyun

AU - Dai, Chang Feng

AU - Sheu, Jyh Horng

PY - 2017

Y1 - 2017

N2 - New steroids, klyflaccisteroids K–M (1–3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2 − [rad]) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.

AB - New steroids, klyflaccisteroids K–M (1–3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2 − [rad]) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.

KW - Anti-inflammatory activity

KW - Cytotoxicity

KW - Klyflaccisteroid

KW - Klyxum flaccidum

KW - Steroid

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U2 - 10.1016/j.bmcl.2017.01.060

DO - 10.1016/j.bmcl.2017.01.060

M3 - 文章

C2 - 28159416

AN - SCOPUS:85011029500

SN - 0960-894X

VL - 27

SP - 1220

EP - 1224

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Klyflaccisteroids K–M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum

Abstract

Bibliographical note

Keywords

UN SDGs

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