Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression

Chi Wei Yeh; Shoa Hsuan Kao; Yi Chuan Cheng; Li Sung Hsu

doi:10.1074/jbc.M112.420265

Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression

Chi Wei Yeh
, Shoa Hsuan Kao
, Yi Chuan Cheng
, Li Sung Hsu^*

^*Corresponding author for this work

Graduate Institute of Biomedical Sciences

Chung Shan Medical University

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

Background: CDK10 is involved in cell proliferation; however, the function of CDK10 in cell development remains unclear. Results: The knockdown of cdk10 results in the apoptosis of neural progenitor cells (NPCs) through enhanced raf1a expression. Conclusion: Zebrafish cdk10 exhibits an important function in neurogenesis by the modulation of the raf1a level during development. Significance: These findings emphasize the significance of cdk10 in NPC survival.

Original language	English
Pages (from-to)	27927-27939
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M112.420265
State	Published - 27 09 2013

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title = "Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression",

abstract = "Background: CDK10 is involved in cell proliferation; however, the function of CDK10 in cell development remains unclear. Results: The knockdown of cdk10 results in the apoptosis of neural progenitor cells (NPCs) through enhanced raf1a expression. Conclusion: Zebrafish cdk10 exhibits an important function in neurogenesis by the modulation of the raf1a level during development. Significance: These findings emphasize the significance of cdk10 in NPC survival.",

author = "Yeh, \{Chi Wei\} and Kao, \{Shoa Hsuan\} and Cheng, \{Yi Chuan\} and Hsu, \{Li Sung\}",

year = "2013",

month = sep,

day = "27",

doi = "10.1074/jbc.M112.420265",

language = "英语",

volume = "288",

pages = "27927--27939",

journal = "Journal of Biological Chemistry",

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T1 - Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression

AU - Yeh, Chi Wei

AU - Kao, Shoa Hsuan

AU - Cheng, Yi Chuan

AU - Hsu, Li Sung

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Background: CDK10 is involved in cell proliferation; however, the function of CDK10 in cell development remains unclear. Results: The knockdown of cdk10 results in the apoptosis of neural progenitor cells (NPCs) through enhanced raf1a expression. Conclusion: Zebrafish cdk10 exhibits an important function in neurogenesis by the modulation of the raf1a level during development. Significance: These findings emphasize the significance of cdk10 in NPC survival.

AB - Background: CDK10 is involved in cell proliferation; however, the function of CDK10 in cell development remains unclear. Results: The knockdown of cdk10 results in the apoptosis of neural progenitor cells (NPCs) through enhanced raf1a expression. Conclusion: Zebrafish cdk10 exhibits an important function in neurogenesis by the modulation of the raf1a level during development. Significance: These findings emphasize the significance of cdk10 in NPC survival.

UR - https://www.scopus.com/pages/publications/84884734639

U2 - 10.1074/jbc.M112.420265

DO - 10.1074/jbc.M112.420265

M3 - 文章

C2 - 23902762

AN - SCOPUS:84884734639

SN - 0021-9258

VL - 288

SP - 27927

EP - 27939

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 39

ER -

Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression

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