TY - JOUR
T1 - Knowledge-Based RapidPlan Volumetric Modulated Arc Therapy Model in Nasopharyngeal Carcinoma
AU - Lu, Szu Huai
AU - Wang, Chun Wei
AU - Liang, Hsiang Kuang
AU - Chang, Chih Kai
AU - Lan, Hao Ting
AU - Lai, Shih Fan
AU - Huang, Bing Shen
AU - Yu Chen, Wan
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/5
Y1 - 2025/5
N2 - Purpose: RapidPlanTM (RP) Eclipse@, a commercial knowledge-based planning software, predicts radiation doses, enhancing treatment planning efficiency and quality. This study developed a nasopharyngeal carcinoma (NPC) volumetric modulated arc therapy RP model and assessed its quality and efficiency against manual plans. Methods and Materials: The existing plans for 160 patients with NPC constituted the RP model training cohort. An additional 33 patients formed a testing cohort to compare RP and manual plans based on dose-volume histograms, isodose curves, physician plan scores, and selection. Results: The RP plan could be completed within 1 hour. RP plans demonstrated superior conformity compared with manual plans in planning target volume 70. RP plans outperformed manual plans in reducing organs-at-risks (OARs) doses. For advanced T3/4 tumors, chiasma and optic nerve doses remained similar to manual plans. RP plans had higher physician-rated scores in dose-volume histograms of targets, OARs, isodose curves, and holistic scores. Clinical plan acceptance rates of RP plans reached 100%. Physicians chose RP plans over manual plans for 31, 30, and 28 patients for doctors A, B, and C, mainly because of superior OAR sparing and higher conformity. Conclusions: The RP plan efficiently generates high-quality NPC volumetric modulated arc therapy plans. Further applications of RP Eclipse in single-institutional clinical flows and multi-institutional collaborations or clinical trials are warranted.
AB - Purpose: RapidPlanTM (RP) Eclipse@, a commercial knowledge-based planning software, predicts radiation doses, enhancing treatment planning efficiency and quality. This study developed a nasopharyngeal carcinoma (NPC) volumetric modulated arc therapy RP model and assessed its quality and efficiency against manual plans. Methods and Materials: The existing plans for 160 patients with NPC constituted the RP model training cohort. An additional 33 patients formed a testing cohort to compare RP and manual plans based on dose-volume histograms, isodose curves, physician plan scores, and selection. Results: The RP plan could be completed within 1 hour. RP plans demonstrated superior conformity compared with manual plans in planning target volume 70. RP plans outperformed manual plans in reducing organs-at-risks (OARs) doses. For advanced T3/4 tumors, chiasma and optic nerve doses remained similar to manual plans. RP plans had higher physician-rated scores in dose-volume histograms of targets, OARs, isodose curves, and holistic scores. Clinical plan acceptance rates of RP plans reached 100%. Physicians chose RP plans over manual plans for 31, 30, and 28 patients for doctors A, B, and C, mainly because of superior OAR sparing and higher conformity. Conclusions: The RP plan efficiently generates high-quality NPC volumetric modulated arc therapy plans. Further applications of RP Eclipse in single-institutional clinical flows and multi-institutional collaborations or clinical trials are warranted.
UR - http://www.scopus.com/inward/record.url?scp=105002015137&partnerID=8YFLogxK
U2 - 10.1016/j.adro.2025.101716
DO - 10.1016/j.adro.2025.101716
M3 - 文章
C2 - 40255218
AN - SCOPUS:105002015137
SN - 2452-1094
VL - 10
SP - 101716
JO - Advances in Radiation Oncology
JF - Advances in Radiation Oncology
IS - 5
M1 - 101716
ER -