Abstract
Three new eunicellin-type diterpenoids, krempfielins N-P (1-3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.
Original language | English |
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Pages (from-to) | 1148-1156 |
Number of pages | 9 |
Journal | Marine Drugs |
Volume | 12 |
Issue number | 2 |
DOIs | |
State | Published - 02 2014 |
Keywords
- Anti-inflammatory agent
- Cladiella krempfi
- Elastase
- Eunicellin-type diterpenoid