Krempfielins N-P, new anti-inflammatory eunicellins from a Taiwanese soft coral Cladiella krempfi

Yan Ning Lee, Chi Jen Tai, Tsong Long Hwang, Jyh Horng Sheu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

22 Scopus citations

Abstract

Three new eunicellin-type diterpenoids, krempfielins N-P (1-3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.

Original languageEnglish
Pages (from-to)1148-1156
Number of pages9
JournalMarine Drugs
Volume12
Issue number2
DOIs
StatePublished - 02 2014

Keywords

  • Anti-inflammatory agent
  • Cladiella krempfi
  • Elastase
  • Eunicellin-type diterpenoid

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