Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

Chi Jen Tai; Uvarani Chokkalingam; Yang Cheng; Shou Ping Shih; Mei Chin Lu; Jui Hsin Su; Tsong Long Hwang; Jyh Horng Sheu

doi:10.3390/ijms151221865

Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

Chi Jen Tai, Uvarani Chokkalingam, Yang Cheng, Shou Ping Shih, Mei Chin Lu, Jui Hsin Su, Tsong Long Hwang, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

Original language	English
Pages (from-to)	21865-21874
Number of pages	10
Journal	International Journal of Molecular Sciences
Volume	15
Issue number	12
DOIs	https://doi.org/10.3390/ijms151221865
State	Published - 27 11 2014

Bibliographical note

Publisher Copyright:
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

Anti-inflammatory activity
Cladiella krempfi
Eunicellin-based diterpenoid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijms151221865

Cite this

@article{abbe07062976436491d98121a1bbb802,

title = "Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi",

abstract = "Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.",

keywords = "Anti-inflammatory activity, Cladiella krempfi, Eunicellin-based diterpenoid",

author = "Tai, {Chi Jen} and Uvarani Chokkalingam and Yang Cheng and Shih, {Shou Ping} and Lu, {Mei Chin} and Su, {Jui Hsin} and Hwang, {Tsong Long} and Sheu, {Jyh Horng}",

note = "Publisher Copyright: {\textcopyright} 2014 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2014",

month = nov,

day = "27",

doi = "10.3390/ijms151221865",

language = "英语",

volume = "15",

pages = "21865--21874",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

TY - JOUR

T1 - Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

AU - Tai, Chi Jen

AU - Chokkalingam, Uvarani

AU - Cheng, Yang

AU - Shih, Shou Ping

AU - Lu, Mei Chin

AU - Su, Jui Hsin

AU - Hwang, Tsong Long

AU - Sheu, Jyh Horng

PY - 2014/11/27

Y1 - 2014/11/27

N2 - Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

AB - Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

KW - Anti-inflammatory activity

KW - Cladiella krempfi

KW - Eunicellin-based diterpenoid

UR - http://www.scopus.com/inward/record.url?scp=84912544842&partnerID=8YFLogxK

U2 - 10.3390/ijms151221865

DO - 10.3390/ijms151221865

M3 - 文献综述

C2 - 25437917

AN - SCOPUS:84912544842

SN - 1661-6596

VL - 15

SP - 21865

EP - 21874

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 12

ER -

Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this