Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

Chi Jen Tai; Uvarani Chokkalingam; Yang Cheng; Shou Ping Shih; Mei Chin Lu; Jui Hsin Su; Tsong Long Hwang; Jyh Horng Sheu

doi:10.3390/ijms151221865

Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

Chi Jen Tai
, Uvarani Chokkalingam
, Yang Cheng
, Shou Ping Shih
, Mei Chin Lu
, Jui Hsin Su
, Tsong Long Hwang
, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

Original language	English
Pages (from-to)	21865-21874
Number of pages	10
Journal	International Journal of Molecular Sciences
Volume	15
Issue number	12
DOIs	https://doi.org/10.3390/ijms151221865
State	Published - 27 11 2014

Bibliographical note

Publisher Copyright:
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-inflammatory activity
Cladiella krempfi
Eunicellin-based diterpenoid

Access to Document

10.3390/ijms151221865

Cite this

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title = "Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi",

abstract = "Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.",

keywords = "Anti-inflammatory activity, Cladiella krempfi, Eunicellin-based diterpenoid",

author = "Tai, \{Chi Jen\} and Uvarani Chokkalingam and Yang Cheng and Shih, \{Shou Ping\} and Lu, \{Mei Chin\} and Su, \{Jui Hsin\} and Hwang, \{Tsong Long\} and Sheu, \{Jyh Horng\}",

note = "Publisher Copyright: {\textcopyright} 2014 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2014",

month = nov,

day = "27",

doi = "10.3390/ijms151221865",

language = "英语",

volume = "15",

pages = "21865--21874",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

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TY - JOUR

T1 - Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

AU - Tai, Chi Jen

AU - Chokkalingam, Uvarani

AU - Cheng, Yang

AU - Shih, Shou Ping

AU - Lu, Mei Chin

AU - Su, Jui Hsin

AU - Hwang, Tsong Long

AU - Sheu, Jyh Horng

PY - 2014/11/27

Y1 - 2014/11/27

N2 - Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

AB - Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

KW - Anti-inflammatory activity

KW - Cladiella krempfi

KW - Eunicellin-based diterpenoid

UR - https://www.scopus.com/pages/publications/84912544842

U2 - 10.3390/ijms151221865

DO - 10.3390/ijms151221865

M3 - 文献综述

C2 - 25437917

AN - SCOPUS:84912544842

SN - 1661-6596

VL - 15

SP - 21865

EP - 21874

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 12

ER -

Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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