L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers

Ling Ling Hsieh; Ren Chang Huang; Ming Whei Yu; Chien Jen Chen; Yun Fan Liaw

doi:10.1016/0304-3835(96)04209-7

L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers

Ling Ling Hsieh^*, Ren Chang Huang, Ming Whei Yu, Chien Jen Chen, Yun Fan Liaw

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

In order to assess associations between the genetic polymorphism of L-myc and glutathione S-transferase M1 (GST M1) and the risk of hepatocellular carcinoma (HCC), a total of 46 surgically treated HCC patients who were seropositive in hepatitis B surface antigen (HBsAg) and 88 HBsAg-positive controls were recruited for this study. L-myc and GST M1 genetic polymorphism was examined using a polymerase chain reaction-based restriction fragment length polymorphism assay on DNA extracted from liver and peripheral blood samples. There was no significant difference in GST M1 genotypes between HCC patients and matched controls. A gene dosage trend of association with HCC risk was observed for L-myc genotype. The dose-response relationship remained statistically significant in the multiple logistic regression analysis.

Original language	English
Pages (from-to)	171-176
Number of pages	6
Journal	Cancer Letters
Volume	103
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(96)04209-7
State	Published - 05 06 1996
Externally published	Yes

Keywords

Glutathione S-transferase M1
Hepatitis B infection
Hepatocellular carcinoma
L-myc

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10.1016/0304-3835(96)04209-7

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title = "L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers",

abstract = "In order to assess associations between the genetic polymorphism of L-myc and glutathione S-transferase M1 (GST M1) and the risk of hepatocellular carcinoma (HCC), a total of 46 surgically treated HCC patients who were seropositive in hepatitis B surface antigen (HBsAg) and 88 HBsAg-positive controls were recruited for this study. L-myc and GST M1 genetic polymorphism was examined using a polymerase chain reaction-based restriction fragment length polymorphism assay on DNA extracted from liver and peripheral blood samples. There was no significant difference in GST M1 genotypes between HCC patients and matched controls. A gene dosage trend of association with HCC risk was observed for L-myc genotype. The dose-response relationship remained statistically significant in the multiple logistic regression analysis.",

keywords = "Glutathione S-transferase M1, Hepatitis B infection, Hepatocellular carcinoma, L-myc",

author = "Hsieh, {Ling Ling} and Huang, {Ren Chang} and Yu, {Ming Whei} and Chen, {Chien Jen} and Liaw, {Yun Fan}",

year = "1996",

month = jun,

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doi = "10.1016/0304-3835(96)04209-7",

language = "英语",

volume = "103",

pages = "171--176",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers

AU - Hsieh, Ling Ling

AU - Huang, Ren Chang

AU - Yu, Ming Whei

AU - Chen, Chien Jen

AU - Liaw, Yun Fan

PY - 1996/6/5

Y1 - 1996/6/5

N2 - In order to assess associations between the genetic polymorphism of L-myc and glutathione S-transferase M1 (GST M1) and the risk of hepatocellular carcinoma (HCC), a total of 46 surgically treated HCC patients who were seropositive in hepatitis B surface antigen (HBsAg) and 88 HBsAg-positive controls were recruited for this study. L-myc and GST M1 genetic polymorphism was examined using a polymerase chain reaction-based restriction fragment length polymorphism assay on DNA extracted from liver and peripheral blood samples. There was no significant difference in GST M1 genotypes between HCC patients and matched controls. A gene dosage trend of association with HCC risk was observed for L-myc genotype. The dose-response relationship remained statistically significant in the multiple logistic regression analysis.

AB - In order to assess associations between the genetic polymorphism of L-myc and glutathione S-transferase M1 (GST M1) and the risk of hepatocellular carcinoma (HCC), a total of 46 surgically treated HCC patients who were seropositive in hepatitis B surface antigen (HBsAg) and 88 HBsAg-positive controls were recruited for this study. L-myc and GST M1 genetic polymorphism was examined using a polymerase chain reaction-based restriction fragment length polymorphism assay on DNA extracted from liver and peripheral blood samples. There was no significant difference in GST M1 genotypes between HCC patients and matched controls. A gene dosage trend of association with HCC risk was observed for L-myc genotype. The dose-response relationship remained statistically significant in the multiple logistic regression analysis.

KW - Glutathione S-transferase M1

KW - Hepatitis B infection

KW - Hepatocellular carcinoma

KW - L-myc

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U2 - 10.1016/0304-3835(96)04209-7

DO - 10.1016/0304-3835(96)04209-7

M3 - 文章

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AN - SCOPUS:0030004968

SN - 0304-3835

VL - 103

SP - 171

EP - 176

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

L-myc, GST M1 genetic polymorphism and hepatocellular carcinoma risk among chronic hepatitis B carriers

Abstract

Keywords

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