Lack of association between CLEC5A gene single-nucleotide polymorphisms and Kawasaki disease in Taiwanese children

Ya Ling Yang, Wei Pin Chang, Yu Wen Hsu, Wei Chiao Chen, Hong Ren Yu, Chi Di Liang, Yao Ting Tsai, Ying Hsien Huang, Kuender D. Yang, Ho Chang Kuo*, Wei Chiao Chang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations


Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD. Methods. A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) of CLEC5A (rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test. Results. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and patients. In the patients, polymorphisms of CLEC5A showed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response. Conclusions. This study showed for the first time that polymorphisms of CLEC5A are not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.

Original languageEnglish
Article number398628
JournalJournal of Biomedicine and Biotechnology
StatePublished - 2012


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