Lack of TEL-AML 1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan

L. Y. Shih; T. B. Chou; D. C. Liang; Y. S. Tzeng; J. E. Rubnitz; J. R. Downing; C. H. Pui

Lack of TEL-AML 1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan

L. Y. Shih^*, T. B. Chou, D. C. Liang, Y. S. Tzeng, J. E. Rubnitz, J. R. Downing, C. H. Pui

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Cryptic t(12;21)(p12-13;q22) leading to TEL-AML1 fusion has recently been recognized as the most frequent genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) in Western countries. More recently, we found a similar frequency of this abnormality in Chinese children with ALL in Taiwan. In this study, we assessed further the frequency of TEL-AML1 fusion as well as that of BCR-ABL in Chinese adults with ALL, using reverse transcriptase-polymerase chain reaction assays. Among the 81 cases with newly diagnosed B lineage ALL studied, none had the TEL-AML1 fusion whereas 30 had the BCR-ABL fusion. The lack of cases with the TEL-AML1 fusion together with the high frequency of BCR-ABL fusion could largely account for the poorer outcome of adult ALL as compared with childhood ALL.

Original language	English
Pages (from-to)	1456-1458
Number of pages	3
Journal	Leukemia
Volume	10
Issue number	9
State	Published - 09 1996
Externally published	Yes

Keywords

Adult acute lymphoblasiic leukemia
B lineage immunophenotype
TEL-AML1 fusion
t(12;21)(p12-13;q22)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{9781424208184954b2c92eefdfcc0a3e,

title = "Lack of TEL-AML 1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan",

abstract = "Cryptic t(12;21)(p12-13;q22) leading to TEL-AML1 fusion has recently been recognized as the most frequent genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) in Western countries. More recently, we found a similar frequency of this abnormality in Chinese children with ALL in Taiwan. In this study, we assessed further the frequency of TEL-AML1 fusion as well as that of BCR-ABL in Chinese adults with ALL, using reverse transcriptase-polymerase chain reaction assays. Among the 81 cases with newly diagnosed B lineage ALL studied, none had the TEL-AML1 fusion whereas 30 had the BCR-ABL fusion. The lack of cases with the TEL-AML1 fusion together with the high frequency of BCR-ABL fusion could largely account for the poorer outcome of adult ALL as compared with childhood ALL.",

keywords = "Adult acute lymphoblasiic leukemia, B lineage immunophenotype, TEL-AML1 fusion, t(12;21)(p12-13;q22)",

author = "Shih, {L. Y.} and Chou, {T. B.} and Liang, {D. C.} and Tzeng, {Y. S.} and Rubnitz, {J. E.} and Downing, {J. R.} and Pui, {C. H.}",

year = "1996",

month = sep,

language = "英语",

volume = "10",

pages = "1456--1458",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature",

number = "9",

}

TY - JOUR

T1 - Lack of TEL-AML 1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan

AU - Shih, L. Y.

AU - Chou, T. B.

AU - Liang, D. C.

AU - Tzeng, Y. S.

AU - Rubnitz, J. E.

AU - Downing, J. R.

AU - Pui, C. H.

PY - 1996/9

Y1 - 1996/9

N2 - Cryptic t(12;21)(p12-13;q22) leading to TEL-AML1 fusion has recently been recognized as the most frequent genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) in Western countries. More recently, we found a similar frequency of this abnormality in Chinese children with ALL in Taiwan. In this study, we assessed further the frequency of TEL-AML1 fusion as well as that of BCR-ABL in Chinese adults with ALL, using reverse transcriptase-polymerase chain reaction assays. Among the 81 cases with newly diagnosed B lineage ALL studied, none had the TEL-AML1 fusion whereas 30 had the BCR-ABL fusion. The lack of cases with the TEL-AML1 fusion together with the high frequency of BCR-ABL fusion could largely account for the poorer outcome of adult ALL as compared with childhood ALL.

AB - Cryptic t(12;21)(p12-13;q22) leading to TEL-AML1 fusion has recently been recognized as the most frequent genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) in Western countries. More recently, we found a similar frequency of this abnormality in Chinese children with ALL in Taiwan. In this study, we assessed further the frequency of TEL-AML1 fusion as well as that of BCR-ABL in Chinese adults with ALL, using reverse transcriptase-polymerase chain reaction assays. Among the 81 cases with newly diagnosed B lineage ALL studied, none had the TEL-AML1 fusion whereas 30 had the BCR-ABL fusion. The lack of cases with the TEL-AML1 fusion together with the high frequency of BCR-ABL fusion could largely account for the poorer outcome of adult ALL as compared with childhood ALL.

KW - Adult acute lymphoblasiic leukemia

KW - B lineage immunophenotype

KW - TEL-AML1 fusion

KW - t(12;21)(p12-13;q22)

UR - http://www.scopus.com/inward/record.url?scp=0029664885&partnerID=8YFLogxK

M3 - 文章

C2 - 8751462

AN - SCOPUS:0029664885

SN - 0887-6924

VL - 10

SP - 1456

EP - 1458

JO - Leukemia

JF - Leukemia

IS - 9

ER -

Lack of TEL-AML 1 fusion transcript resulting from a cryptic t(12;21) in adult B lineage acute lymphoblastic leukemia in Taiwan

Abstract

Keywords

UN SDGs

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