Laser-Assisted Drug Delivery of Tranexamic Acid by Picosecond Laser in Postinflammatory Hyperpigmentation: A Split-Area Double Blind Randomized Prospective Study

Cen Hung Lin, Yueh Ju Tsai, Ko Chien Lin, Mu Han Hsieh, Hui Ping Lin, Shiun Yuan Hsu, Hui Hong Tsai, Ching Hua Hsieh*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Background: Tranexamic acid has been reported to benefit the treatment of postinflammatory hyperpigmentation (PIH). Laser-Assisted drug delivery (LADD) could facilitate the efficacy of topically applied drugs into the dermis. This split-Area randomized prospective study aims to assess whether early utilization of the LADD procedure with tranexamic acid delivery followed by picosecond lasers can attenuate the PIH better than the utilization of picosecond lasers alone. Patients and methods: Ten post-Traumatic cases of PIH in 10 patients (8 female and 2 male) with an average age of 34.2 ± 11.2 years were included in this clinical trial. Using block randomization to determine the treatment side, one side of each area of the PIH was separated from the midline into two halves belonging to the control and tranexamic acid groups. The half area of the tranexamic acid group was further topically applied with 10% tranexamic acid solution. This procedure was repeated every 6 weeks, four times in total. Results: The self-Assessment of the hyperpigmentation and overall satisfaction of the treatment outcome were not significantly different between the treatment and control sides. Conclusions: This split-Area study revealed that, compared with picosecond alone, there was no significant difference adopting tranexamic acid in LADD after nonablative fractional picosecond laser for PIH.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalPhotobiomodulation, Photomedicine, and Laser Surgery
Volume39
Issue number11
DOIs
StatePublished - 11 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.

Keywords

  • fractional
  • laser-Assisted drug delivery
  • nonablative
  • picosecond laser
  • postinflammatory hyperpigmentation
  • tranexamic acid

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