Left atrial enlargement induced by pure mitral regurgitation: Time frame in a new swine model

J. P. Chang*, T. H. Tsai, Y. L. Chen, Y. H. Wang, W. C. Ho, G. H. Yu, M. C. Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations

Abstract

Background: Atrial enlargement occurs in patients with significant mitral regurgitation. However, the time frame of the development of atrial enlargement induced by mitral regurgitation remains unknown. Methods: Fourteen Lanyu miniature pigs (age = 6.6 ± 0.9 months) were studied. Mitral regurgitation was created by placing a predefined hole on the middle scallop of the posterior mitral leaflet under cardiopulmonary bypass. The parasternal long-axis atrial dimension was measured by transthoracic echocardiographic examinations. Results: All animals exhibited grade 3 mitral regurgitation immediately after surgery. Seven pigs expired within 2 weeks after the operation [technical complications (n = 1), acute cardiac tamponade (n = 1), and acute and subacute heart failure (n = 5)]. Seven pigs remained alive at a mean follow-up of 7.7 ± 2.1 months. The left atrial diameter indices of the 7 pigs increased significantly at 1 month (33.1 ± 8.6 mm, p = 0.018) and 3 months (41.3 ± 12.6 mm, p = 0.018) after surgery compared with baseline values (22.8 ± 5.2 mm), and the left atrial diameter index increased significantly at 3 months compared to 1 month (p = 0.018). Conclusions: Left atrial enlargement develops rapidly and progresses after the creation of significant pure mitral regurgitation.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalEuropean Surgical Research
Volume45
Issue number2
DOIs
StatePublished - 10 2010

Keywords

  • Atrium
  • Mitral valve insufficiency

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