Leucocyte apoptosis in patients with acute ischaemic stroke

Nai Wen Tsai, Wen Neng Chang, Chen Fu Shaw, Chung Ren Jan, Cheng Hsien Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations

Abstract

1. Inflammation and activated leucocytes are involved in the pathogenesis of acute ischaemic stroke. Leucocyte apoptosis is critical for the efficient resolution of inflammation. Little is known about the correlation between leucocyte apoptosis and acute ischaemic stroke (AIS). The objective of the present study was to evaluate the role of leucocyte apoptosis in patients with AIS. 2. Serial changes in leucocyte apoptosis and the apoptosis of leucocyte subsets (i.e. neutrophils, monocytes and lymphocytes), as determined by flow cytometry, were examined prospectively at various time-points in 50 patients with AIS and 50 controls using the APO 2.7 antibody. 3. Leucocyte apoptosis and the apoptosis of leucocyte subsets were significantly lower in stroke patients than in the control group (P < 0.01). The percentage apoptosis of total leucocytes and neutrophils was significantly lower in the group with large-artery disease than in the group with small-atery disease (P < 0.01). Leucocyte apoptosis was lowest during the acute stage of ischaemic stroke and increased thereafter. 4. Leucocyte apoptosis may reflect the inflammatory status after AIS. A better understanding of the mechanisms underlying leucocyte apoptosis in ischaemic stroke may lead to the development of new strategies to improve the outcome for stroke patients.

Original languageEnglish
Pages (from-to)884-888
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume37
Issue number9
DOIs
StatePublished - 09 2010

Keywords

  • APO 2.7 antibody
  • flow cytometry
  • inflammation
  • ischaemic stroke
  • leucocyte apoptosis

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