Leukocyte adhesion deficiency disorder: Report of one case

Chih Hsing Hung*, Shin Nan Cheng, Yi Ming Hua, Chih Lu Wang, Yuan Hao Chen, Kuender D. Yang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations

Abstract

In this paper, a case of leukocyte adhesion deficiency disorder confirmed by flow cytometry and leukocyte chemotaxis assays is reported. The 32-day-old female infant was admitted to our ward on account of delayed umbilical cord detachment and omphalitis. After admission, hemogram revealed severe leukocytosis (white blood cell (WBC) counts: 86,8001 cumm), and there was poor clinical response to several kinds of antibiotics. The above history indicated that the patient might be a case of leukocyte adhesion deficiency disorder. A definite absence of CD11b/CD18 adhesion molecule on the patient's granulocytes and severe defects of leukocyte function demonstrated by chemotaxis, chemokine-sis and zymosan-induced respiratory burst assays confirmed this diagnosis.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalZhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui
Volume40
Issue number2
StatePublished - 1999
Externally publishedYes

Keywords

  • Adhesion molecule
  • Chemotaxis
  • Leukocytosis

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