Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon

Jiin Chyuan Luo, Alfred I. Neugut, Gail Garbowski, Kenneth A. Forde, Michael Treat, Steven Smith, Walter P. Carney, Paul W. Brandt-Rauf*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

38 Scopus citations

Abstract

Plasma levels of p53 protein were examined by an enzyme linked immunosorbent assay in 184 patients enrolled in a colonoscopy study. The mean levels among 47 individuals with normal colonoscopic examinations and no prior history of colonic neoplasia (0.12 ng/ml) and among 61 individuals with normal colonoscopic examinations and a prior history of colonic neoplasia (0.09 ng/ml) were similar. However, the mean levels among 54 individuals with newly diagnosed colonic adenomas (0.44 ng/ml) and 22 individuals with newly diagnosed colonic carcinomas (0.55 ng/ml) were statistically significantly elevated compared to the normal controls (P < 0.02). Among these tumor patients, the plasma levels tended to increase with increasing adenoma size and with increasing carcinoma stage, although these trends were not statistically significant. Defining a significant positive plasma level as any value greater than ten times background, the percentage of positive samples increased from 4% in the controls to 20% in the adenoma cases to 32% in the carcinoma cases. These results demonstrate that plasma p53 protein levels are elevated in a subgroup of individuals with colonic neoplasia.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalCancer Letters
Volume91
Issue number2
DOIs
StatePublished - 08 05 1995
Externally publishedYes

Keywords

  • Colonic adenomas
  • Colonic carcinomas
  • Plasma biomarker
  • p53

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