Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)

Sean W. Reilly, Aladdin A. Riad, Chia Ju Hsieh, Kristoffer Sahlholm, Daniel A. Jacome, Suzy Griffin, Michelle Taylor, Chi Chang Weng, Kuiying Xu, Nathan Kirschner, Robert R. Luedtke, Christopher Parry, Shipra Malhotra, John Karanicolas, Robert H. Mach*

*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Fingerprint

Dive into the research topics of 'Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs)'. Together they form a unique fingerprint.

Pharmacology, Toxicology and Pharmaceutical Science

Biochemistry, Genetics and Molecular Biology