Abstract
Background/Aims: The differentiation of hepatocellular carcinoma from benign liver diseases in hepatitis B virus carriers by imaging studies based upon morphological aspects can be difficult. Methodology: FDG-PET (18F-2-deoxyglucose positron emission tomographies) were performed in 48 hepatitis B virus carriers to detect hepatocellular carcinoma and differentiate other benign liver diseases. In each patient, the focal liver lesion was visible by ultrasound and an elevated serum alpha-fetoprotein level was noted. Definite diagnosis was established after ultrasound-guided liver biopsy followed by histopathological examination. Results: The histopathological examination revealed hepatocellular carcinoma in 36 patients and benign liver diseases in the remaining 12 patients. Twenty of 36 hepatocellular carcinomas were detectable by FDG-PET and none of 12 benign liver diseases were visualized by FDG-PET. The detection sensitivity of FDG-PET was not related to the echogenicity and size of hepatocellular carcinoma. Conclusions: FDG-PET is not sensitive to but is more specific than ultrasound and serum alpha-fetoprotein level to detect hepatocellular carcinoma and differentiate from other benign liver diseases in hepatitis B virus carriers.
| Original language | English |
|---|---|
| Pages (from-to) | 2154-2156 |
| Number of pages | 3 |
| Journal | Hepato-Gastroenterology |
| Volume | 50 |
| Issue number | 54 |
| State | Published - 11 2003 |
| Externally published | Yes |
Keywords
- Fluorine-18-fluorodeoxyglucose
- Hepatitis B virus carrier
- Hepatocellular carcinoma
- Positron emission tomography
